Gastroenterologia Japonica

, Volume 16, Issue 3, pp 268–274 | Cite as

A pancreatic oncofetal antigen: its partial purification and clinical application

  • Tatsuji Homma
  • Hisao Oguchi
  • Shigeyuki Kawa
Original Article


Studies on the purification, characterization and clinical application of pancreatic oncofetal antigen were reported. This antigen was purified from fetal pancreas, and migrated in the β-region on electrophoresis. Its molecular weight was about 80 x 104 daltons on gel filtration with a Sephacryl S-300. This antigen is clearly different from other oncofetal antigens such as alfafetoprotein, carcinoembryonic antigen or ferritin. Clinically, this pancreatic oncofetal antigen was positive in sera of 68.4% of the patients with pancreatic cancer. However, elevated level of this antigen was also observed in the sera of some patients with bilialy tract cancer, colon cancer or gastric cancer. The antigen was also found in pancreatic juice obtained from patients with pancreatic cancer in almost the same incidence as in their sera.

It is suggested that a pancreatic oncofetal antigen assay of sera and pancreatic juice in combination with other oncofetal antigens is valuable for the diagnosis and monitoring the clinical course of pancreatic cancer.

Key Words

pancreatic oncofetal antigen pancreatic cancer tumor-associated antigen 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Banwo O, et al: New oncofetal antigen for human pancreas. Lancet 1: 643–645, 1974PubMedCrossRefGoogle Scholar
  2. 2).
    Gelder FB, et al: Purification, partial characterization and clinical evaluation of a pancreatic oncofetal antigen. Cancer Res 38: 313–323, 1978PubMedGoogle Scholar
  3. 3).
    Oda M, et al: Immunological approach to the diagnosis of pancreatic cancer (1). Proc Jap Pancr Dis Assoc 5th Annal Meeting 4(1): 53–54, 1973 (Jpn)Google Scholar
  4. 4).
    Oguchi H: Immunological approach to the diagnosis of pancreatic cancer using embryonal pancreatic protein. Shinshu Med J 26: 43–54, 1978 (Jpn)Google Scholar
  5. 5).
    Homma T: A research of immunological diagnostic method for pancreatic cancer using embryonal pancreatic protein. Ann Rep Co-ope Res (Can) Minist Educ: 593–596, 1980 (Jpn)Google Scholar
  6. 6).
    Cuatrecasas P, et al: Selective enzyme purification by affinity chromatography. Proc Natl Acad Sci USA 61: 636–643, 1968PubMedCrossRefGoogle Scholar
  7. 7).
    Andrews P: Estimation of the molecular weights of proteins by Sephadex gel-filtration. Biochem J 91: 222–233, 1964PubMedGoogle Scholar
  8. 8).
    Tatarinov YS: New data on the embryospecific antigenic components of human blood serum. Fed Proc 24: T916–918, 1965 (Vop Med Khim 10: 584, 1964)Google Scholar
  9. 9).
    Gold P, et al: Demonstration of tumor-specific antigens in human colonie carcinomata by immunological tolerance and absorption techniques. J Exp Med 121: 439–462, 1965PubMedCrossRefGoogle Scholar
  10. 10).
    Gold P, et al: Specific carcinoembryonic antigens of the human digestive system. J Exp Med 122: 467–481, 1965PubMedCrossRefGoogle Scholar
  11. 11).
    Chu TM, et al: Isolation of a Glycoprotein antigen from ascites fluid of pancreatic carcinoma. Cancer Res 37: 1525–1529, 1977PubMedGoogle Scholar
  12. 12).
    Kuntz DJ, et al: Extraction and identification of a human pancreatic tumor-associated antigen. Oncology 36: 134–138, 1979PubMedCrossRefGoogle Scholar
  13. 13).
    Schultz DR, et al: Tumor-associated antigen in human pancreatic cancer. J Nat Cancer Inst 62: 777–785, 1979PubMedGoogle Scholar
  14. 14).
    Ona FV, et al: Carcinoembryonic antigen (CEA) in the diagnosis of pancreatic cancer. Cancer 31: 324–327, 1973PubMedCrossRefGoogle Scholar
  15. 15).
    Marcus DM, et al: Isolation of ferritin from human mammary and pancreatic carcinomas by means of antibody immunoadsorbents. Arch Biochem Biophys 162: 493–501, 1974PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1981

Authors and Affiliations

  • Tatsuji Homma
    • 1
  • Hisao Oguchi
    • 1
  • Shigeyuki Kawa
    • 1
  1. 1.The Second Department of Internal MedicineShinshu University School of MedicineMatsumotoJapan

Personalised recommendations