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Physiological similarity and bioreactor scale-up

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Abstract

An economically effective transfer of biological processes from laboratory to production scale is the main task of microbial process engineering. In contrast to the principle of geometrical, chemical, thermal, hydrodynamic or chemical similarity, recommended for scale-up of chemical reactors we propose the principle of physiological similarity. According to this principle same the microenvironment of the living cell must be established to reproduce the same physiological function (e.g. growth, product formation or substrate consumption rates) in the large scale bioreactor as in the laboratory one.

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Abbreviations

a :

exponent in rate equations (see Table II)

b :

birth rate

c :

specific heat

C :

concentration

d :

death rate or impeller diameter

D :

diffusion coefficient or diameter

g :

gravity constant

k, K :

kinetic constants (see Table II)

kLa:

aeration capacity

L :

length

n :

rotation speed

p, P :

pressure (quantity and dimension)

R :

reaction rate

S R :

reaction heat

v, V :

velocity (quantity and dimension)

Y :

yield coefficient

α,β:

coefficients of interface heat and mass transfer

ρ:

density

μ:

viscosity

σ:

surface tension

∇:

Laplace operator

Δ:

difference operator

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  1. Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20, Prague 4

    J. Votruba & M. Sobotka

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  1. J. Votruba
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  2. M. Sobotka
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Votruba, J., Sobotka, M. Physiological similarity and bioreactor scale-up. Folia Microbiol 37, 331–345 (1992). https://doi.org/10.1007/BF02815659

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  • DOI: https://doi.org/10.1007/BF02815659

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