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Molecular and Chemical Neuropathology

, Volume 31, Issue 1, pp 65–72 | Cite as

Lithium prevents ouabain-induced behavioral changes

Toward an animal model for manic depression
  • Rena Li
  • Rif S. El-Mallakh
  • Linda Harrison
  • David G. Changaris
  • Robert S. Levy
Original Articles

Abstract

Both mania and bipolar depression have been associated with decrements in the activity of the sodium and potassium-activated adenosine triphosphatase (Na,K-ATPase) membrane pump. Although the role of this observation in the pathophysiology of bipolar illness is unclear, it has been proposed that this defect could be central to the pathogenesis of the illness. In an effort to test this hypothesis, the authors examined the efficacy of lithium pretreatment in attenuating behavioral changes secondary to acute administration of a single intracerbroventricular (icv) dose of the Na,K-ATPase-inhibiting compound, ouabain, in the Sprague-Dawley rat. Ouabain (10−3 M) significantly decreased motor activity in automated activity monitors. Lithium pretreatment for 7 d totally prevented this effect. These preliminary data suggest that icv ouabain administration in the rat may prove to be a viable animal model for bipolar illness.

Index Entries

Bipolar disorder cardiac glycosides lithium Na,K-ATPase manic-depressive disorder ouabain sodium pump 

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Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • Rena Li
    • 1
  • Rif S. El-Mallakh
    • 1
  • Linda Harrison
    • 2
  • David G. Changaris
    • 2
  • Robert S. Levy
    • 2
  1. 1.Mood Disorders Research ProgramUniversity of Louisville School of MedicineLouisville
  2. 2.The Laboratory of Biological Psychiatry, Departments of Psychiatry, Biochemistry, and NeurologyUniversity of Louisville School of MedicineLouisville

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