Characterization of the limited specificity of antigen recognition in earthworms
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Earthworms respond to parenteral stimulation with a protein antigen by the formation of an antigen-binding protein. Earthworms were parenterally stimulated with different proteins and the protein binding was estimatedin vitro on both humoral and cellular levels. The binding was significantly higher when the same protein was used forin vivo stimulation. The degree of specificity of the antigen-binding protein after the secondaryin vivo challenge increased, but even so it was considerably lower than that of vertebrate immunoglobulins.
KeywordsHuman Serum Albumin Protein Antigen Coelomic Fluid Coelomic Cavity Parenteral Stimulation
Lumbricus balanced salt solution
arsanylated human serum albumin
bovine serum albumin
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- Cooper E.L., Roch P.: Immunological profile of annelids: Transplantation immunity, pp. 201–243 inImmunology of Annelids (V. Větvička, P. Šíma, E.L. Cooper, M. Bilej, P. Roch, Eds). CRC Press, Boca Raton-Ann Arbor-London-Tokyo 1994.Google Scholar
- Tučková L., Rejnek J., Bilej M., Hájková H., Romanovský A.: Monoclonal antibodies to antigen binding protein of annelids (Lumbricus terrestris).Comp. Biochem. Physiol. 100B, 19–23 (1991b)Google Scholar