Gastroenterologia Japonica

, Volume 19, Issue 5, pp 472–478 | Cite as

A case report of benign recurrent intrahepatic cholestasis

  • Michio Lee
  • Hisao Hayashi
  • Nobuo Sakamoto
  • Sumihiko Okuyama
Case Report


A case of benign recurrent intrahepatic cholestasis was reported. A man had first experienced jaundice at the age of twenty-five, and suffered three subsequent attacks over the next five years. These attacks were characterized by prodromal severe pruritus.

During the icteric phase, serum levels of total bile acids increased, most being conjugates of primary bile acids. Electron microscopy revealed that the bile canaliculi were filled with an increased volume of granular substances. Some bile canaliculi fused together resulting in the formation of abnormally elongated channels which abutted on the Disse space. These observations suggest bile regurgitation through the channel of altered canaliculi. In convalescence, these bile canaliculi disappeared. Every attack was followed by complete recovery of liver structure and function.

Key Words

Cholestasis Bile acids Electronmicroscopy 


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Copyright information

© The Japanese Society of Gastroenterology 1984

Authors and Affiliations

  • Michio Lee
    • 1
  • Hisao Hayashi
    • 1
  • Nobuo Sakamoto
  • Sumihiko Okuyama
    • 2
  1. 1.3rd Department of MedicineNagoya University School of MedicineNagoyaJapan
  2. 2.Nagoya University College of Medical TechnologyNagoyaJapan

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