Gastroenterologia Japonica

, Volume 27, Issue 6, pp 745–750 | Cite as

The effect of IL-6 on the des-gamma-carboxy prothrombin synthesis in human hepatoma cells

  • Minoru Ono
  • Hironobu Kohda
  • Tooru Naraki
  • Hitoyoshi Ohta
  • Motoyuki Ohhira
  • Chihiro Sekiya
  • Masayoshi Namiki
Liver, Pancreas and Biliary Tract


Effects of several cytokines on des-gamma-carboxy prothrombin (PIVKA II) synthesis in human hepatoma cells were investigated to know the process of PIVKA II production during a liver allograft rejection. Human recombinant interleukin-6 (IL-6) significantly stimulated the PIVKA II synthesis without any influence on the cell proliferation. The effect was almost completely neutralized by the specific anti-IL-6 antibody. Neither tumor necrosis factor (TNF), interleukin-1 (IL-1) nor interferon-gamma (IFN-gamma) had such a stimulative effect. IL-6 appears to stimulate PIVKA II production, and would be a candidate of factors that enhance the production of PIVKA II during a liver allograft rejection.

Key words

IL-6 des-gamma-carboxy prothrombin hepatocellular carcinoma 

The abbreviations used


des-gamma-carboxy prothrombin


tumor necrosis factor








enzyme-linked immunosorbent assay


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Copyright information

© The Japanese Society of Gastroenterology 1992

Authors and Affiliations

  • Minoru Ono
    • 1
  • Hironobu Kohda
    • 1
  • Tooru Naraki
    • 1
  • Hitoyoshi Ohta
    • 1
  • Motoyuki Ohhira
    • 1
  • Chihiro Sekiya
    • 1
  • Masayoshi Namiki
    • 1
  1. 1.Third Departments of Internal MedicineAsahikawa Medical CollegeHokkaidoJapan

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