Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone
Male Wistar rats bearing intracerebroventricular (ICV) cannulae and with simultaneous access to 6% ethanol and water were subjected to adrenalectomy (ADX) or sham surgery. ADX decreased ethanol intake. Starting a few days later, the animals received ICV infusions with 100 μg corticosterone acetate (CORT) with 2-to 3-day intervals for 2 weeks. ICV CORT, but not SC CORT at the same dose, restored ethanol consumption in ADX rats to preoperative levels, whereas vehicle infusions (propylene, glycol) did not. Adrenally intact animals, which normally consumed moderate amounts of ethanol (≈0.5 g/kg per day), also showed a robust effect of ICV infusions of CORT, whereas this facilitatory effect was not observed in high consumers (≈3.0 g/kg per day). The suppressive effect of ADX on ethanol intake was not reproduced by concurrent and repeated ICV infusions of intracellular mineralocorticoid (RU 28318) and glucocorticoid (mifepristone) receptor blockers. It is concluded that CORT stimulates alcohol consumption by acting in the brain, probably by way of neuronal membrane mechanisms.
Key wordsAlcohol drinking Adrenalectomy Corticosterone Drug abuse Mifepristone RU 28318 RU 38486 Interacerebroventricular infusions
Unable to display preview. Download preview PDF.
- Fahlke C, Hård E, Eriksson CPJ, Engel JA, Hansen S (1995) Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosterone receptor antagonists. Psychopharmacology 117: 216–224PubMedCrossRefGoogle Scholar
- Ganong WF (1987) Review of medical physiology., Appleton & Lange, NorwalkGoogle Scholar
- Hansen S, Fahlke C, Hård E, Engel JA (1994) Adrenal corticosteroids modulate the consumption of ethanol in the rat. In: Palomo T, Archer T (eds) Strategies for studying brain disorders: depressive, anxiety and abuse disorders. Farand, Press, London, pp 465–479Google Scholar
- Marinelli M, Piazza PV, Barrot M, Rougé-Pont F, Kharoby M, Le Moal M, Simon H (1994) Glucocorticoids and drug abuse: influences of acute inhibition of corticosterone synthesis and administration of corticosteroid receptor antagonists on cocaine-induced locomotion. Soc Neurosci Abstr 20: 666.6Google Scholar
- Mendelson SD, McEwen BS (1992) Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 1B receptors in the dorsal hippocampus and cortex of the rat. Neuroendocrinol 55: 444–50Google Scholar
- Philibert D, Moguilewski M, Mary I, Lecaque D, Tornemine C, Secchi C, Deraedt R (1985) Pharmacological profile of RU 486 in animals. In: Baulieu EE, Segal SH (eds) The antiprogestin steroid RU 486 and human fertility control. Plenum. New York. pp 49–68Google Scholar
- Piazza PV, Deroche V, Rougé-Pont F, Deminière JM, Maccari S, Le Moal M, Simon H (1992) Individual differences in the sensitivity to corticosterone’s reinforcing effets and in corticosterone-induced dopamine release may be a biological, basis for sensation-seeking. Soc Neurosci Abstr 449: 13Google Scholar