Abstract
We studied the pulsatile luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretory patterns, at early or intermediate years of menopause in seven normal women with different degrees of obesity, taking blood samples every minute for 40 min to 2 h. The hormones were assayed with an immunoradiometric assay (IRMA) system, analyzing with the cluster pulse algorithm. All women showed hormone pulses every 8–10 min. In five of them were found periods of discrete pulses with oscillations of high amplitude alternating with periods of pulses of low amplitude. In two cases, the high-frequency oscillatory pattern with low amplitude was found around low mean levels of 22.8 and 25.7 IU/L. The LH oscillatory pattern also had a high frequency, but at a lower level, giving a high FSH/LH ratio. The coincidence index of FSH with LH peaks was 76.6%. We concluded that at menopause, the frequency of FSH and LH secretion increases with a high FSH/LH ratio. Obese menopausal women may have the same high-frequency oscillatory patterns, but at low levels.
Similar content being viewed by others
References
Santoro, N., Butler, J. P., Filicori, M., and Crowley, W. F., Jr., (1988).Am. J. Physiol. 255, PE696–701.
Veldhuis, J. D., Evans, W. S., Rogol, A. D., Thorner, M. O., Drake, C. R., Merriam, G. R., and Johnson, M. L. (1984).J. Clin. Endocrinol. Metab. 59, 96–102.
Knobil, E. and Yen, S. S. C. (1996).Science 274, 18.
Veldhuis, J. D., Iranmanesh, A., Clarke, I., Kaiser, D. L., and Johnson, M. L. (1989).J. Neuroendocrinol. 1, 185–194.
Veldhuis, J. D., Johnson, M. L., and Seneta, E. (1991).J. Clin. Endocrinol. Metab. 73, 569–576.
Velasco, E., Malacara, J. M., Diaz de León, J., Cervantes, F., Dávalos, G., and Castillo, J. (1990).Fertil. Steril. 53, 56–60.
Medina, M., Scaglia, H. E., Vazquez, Gi, Aiatorre, S., and Pérez-Palacios, G. (1976).J. Clin. Endocrinol. Metab. 43, 1015–1019.
Kletzky, O. A., Fossum, F. T., and Greep, N. (1990). Luteinizing and folliclestimulating hormone pulsatile variability in postmenopausal women.Ann. NY Acad. Sci. 752, 438–440.
Rossmanith, W. G., Reichelt, C., and Sherbaum, W. A. (1994).Neuroendocrinology 59, 355–362.
Yen, S. S. C., Tsai, C. C., Naftolin F., Vandenberg, G., and Ajabor, L. (1972).J. Clin. Endocrinol. Metab. 34, 671–675.
Wise, P. M., Krajnan, K. M., Kashon, M. L. (1996).Science 273, 67–70.
Reame, N. E., Kelch, R. P., Beitins, I. Z., Yu, M-Y., Zawacki, C. M., and Padmanabhan, V. (1996).J. Clin. Endocrinol. Metab. 81, 1512–1518.
Iranmanesh, A., Lizarralde, G., Short, D., and Veldhuis, J. D. (1990).J. Clin. Endocrinol. Metab. 71, 1276–1283.
Ulloa-Aguirre, A., Midgley, A. R., Jr., Beitins, I. Z., and Padmanabhan, V. (1995).Endocr. Rev. 16, 765–787.
Padmanabhan, V., Kelch, R. P., Sonstein, J., Foster, C. M. and Beitins, I. Z. (1988).J. Clin. Endocrinol. Metab. 67, 793–800.
Padmanhabam, V., McFadden, K., Mauger, D. T., Karsh, F. J., and Midgley, Jr., A. R. (1997).Endocrinology 138, 424–432.
Edman, C. D. and MacDonald, P. D. (1978).Am. J. Obstet Gynecol 130, 456–461.
Hosseinian, A. H., Kim, M. H., and Rosenfield, R. L. (1976).J. Clin. Endocrinol. Metab. 42, 765–769.
O’Dea, J. P. K., Weiland, R. G., Hallberg, M. C., Llerena, L. A., Zorn, E. M., and Genuth, S. M. (1979).J. Lab. Clin. Med. 93, 1004–1008.
Judd, H. L., Davidson, B. J., Frumar, A. M., Shamonki, I. M., Lagasse, L. D., and Gallon, S. C. (1980).Am. J. Obstet. Gynecol. 136, 859–871.
Staviaky, K. M., Collins, J. A., Donner, A., and Wells, G. A. (1981).Am. J. Obstet. Gynecol. 141, 547–554.
Daniel, W. H. (1976).Arch. Intern. Med. 136, 298–304.
Veldhuis, J. D. and Johnson, M. L. (1988).Am. J. Physiol. 255, 974–993.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Huerta, R., Malacara, J.M., Fajardo, M.E. et al. High-frequency FSH and LH pulses in obese menopausal women. Endocr 7, 281–286 (1997). https://doi.org/10.1007/BF02801320
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02801320