International Journal of Pancreatology

, Volume 3, Issue 2–3, pp 209–216 | Cite as

Antioxidants to treat chronic pancreatitis in childhood?

Case report and possible implications for pathogenesis
  • J. M. Braganza
  • A. Thomas
  • A. Robinson
Case Report


The case history of a 10-yr old boy with calcific chronic pancreatitis is reported. His theophylline clearance of 450 ml/kg/h was several times higher than normal, indicating induction of cytochromes P450. Painful attacks disappeared concurrently with administration of antioxidants. The possible relevance of these findings is discussed in the context of chronic pancreatitis in childhood.

Key words

Childhood pancreatitis Cytochrome P450 Oxygen free radicals Theophylline test Antioxidants 


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Copyright information

© Elsevier Science Publishers B.V. (Biomedical Division) 1988

Authors and Affiliations

  • J. M. Braganza
    • 1
  • A. Thomas
    • 1
  • A. Robinson
    • 1
  1. 1.Department of GastroenterologyThe Royal InfirmaryManchesterU.K.

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