Abstract
This paper describes the application of a simple log-linear model to suspension cultures of the species Catharanthus roseus G. Don. Data obtained experimentally have been interpolated by a cubic spline to give data points of regular time period. A logarithmic transformation has been applied and a linear model fitted to these transformed variables. The results show that there is a reasonable fit to the experimental data cited.
Using this model a one-step ahead prediction is made for a series of untried experimental variables, and the results generated are compared with the experimental data subsequently obtained.
Similar content being viewed by others
References
Fowler, M. W. (1982),Biochem. Soc. Trans. 11, 23.
Smart, N. J. (1984),Lab. Practice 33, 1, 11–36.
Staba E.J., ed. (1980),Plant Tissue Culture as a Source of Biochemicals, Boca Raton, Florida, CRC Press.
Morris, P., and Fowler, M. W. (1980),Biochem. Soc. Trans. 8, 638.
Zenk, M. H., El-Shagi, H.,Arens, H., Stockigt, H., Weiler, E. W., and Deus, B. (1978), inPlant Cell Culture and Its Biotechnological Application, Barz, W., Reinhard, E., and Zenk, M. H. (eds.), Springer-Verlag, Berlin, pp. 27–43.
Street, H. E. (1973),Plant Tissue and Cell Culture, Blackwells Botanical Monographs, Oxford.
Pareilleux, A., and Chaubet, N. (1980),Biotechnol. Lett. 2 (6), 291.
Contois, D. E. (1959),J. Gen. Microbiol. 21, 40.
Aiba, S., Shoda, M., and Nagatani, M. (1968),Biotechnol. Bioeng. 10, 845.
Murashige, T., and Skoog, F. (1962),Physiol. Plant 15, 473.
Fowler, M. W. (1983), inPlant Biotechnology, Mantell, S. H., and Smith, H., eds., Society for Experimental Biology Seminar Series and Cambridge University Press, Cambridge, pp. 3–37.
Wilson, S. B., King, P., and Street, H. E. (1971),J. Exp. Bot. 21, 177.
Handel, E. van. (1968),Anal. Biochem. 22, 280.
Karim, M. N., Mureira, A. R., and Grogen, A. (1982), Modelling and Actaptive Control of a Fermentation System, inProceedings of the 1982 American Control Conference, vol.3. pp. 925–930.
Cox, M. G. (1975),J. Inst. Math. Appl. 15, 95.
Strejc, V. (1980),Automatica 16, 535.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bailey, C., Nicholson, H., Morris, P. et al. A simple model of growth and product formation in cell suspensions ofCatharanthus roseus G. Don. Appl Biochem Biotechnol 11, 207–219 (1985). https://doi.org/10.1007/BF02798477
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02798477