Abstract
Female broiler chicks receiving an ip injection of Fe (10 mg/kg bw) were found to have a greatly increased level of hepatic metallothionein. The increase in metallothionein was not correlated with changes in serum corticosterone. Attempts to vary serum corticosterone levels by feeding metyrapone, an 11-β steroid hydroxylase inhibitor, were unsuccessful.
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References
J. H. R. Kagi, S. Himmelhoch, P. Whanger, J. Bethune, and B. Vallee,J. Biol. Chem. 249, 3537 (1974).
M. Margoshes, and B. Vallee,J. Amer. Chem. Soc. 79, 4813 (1957).
M. P. Waalkes, M. J. Harvey, and C. D. Klaassen,Toxicol. Lett. 20, 33 (1984).
C. McCormack,Proc. soc. Exp. Biol. and Med. 176, 392 (1984).
S. H. Oh, J. T. Deagen, P. D. Whanger, and P. H. Weswig,Am. J. Physiol. 234, E282 (1978).
C. D. Klaassen,Toxicol. 20, 275 (1981).
P. Z. Sobocinski, W. J. Canterbury, C. A. Mapes, and R. E. Dinterman,Am. J. Physiol. 234, E399 (1978).
K. R. Etzel, S. G. Shapiro, and R. J. Cousins,Biochem. and Biophys. Res. Commun. 89(4), 1120 (1979).
J. A. Thomas, and M. G. Mawhinney,Synopsis of Endocrine Pharmacology, Univ. Park Press, Baltimore, MD, 1973.
B. E. P. Murphy,J. Clin. Endocrin. 27, 973 (1967).
H. S. Siegel, N. R. Gould, and J. W. Latimer,Proc. Soc. Exp. Biol. and Med. 178, 523 (1985).
D. L. Eaton, and B. F. Toal,Toxicol. Appl. Pharmacol. 66, 134 (1982).
A. B. Myles, and J. R. Daley,Corticosterone and ACTH Treatment. Principles and Problems, Edward Arnold, London, 1974.
L. E. Edqvist, and E. D. B. Johansson, “Radioimmunoassay and Competitive Binding Protein for Measurement of Certain Steroid Hormones in Farm animals,” inIsotope Studies on the Physiology of domestic Animals (Athens, Greece International Atomic Energy Agency, Vienna, 1972), pp. 245–258.
D. L. Thompson, K. D. Elgert, W. B. Gross, and P. B. Siegel,Am. J. Vet. Res. 41(1), 91 (1980).
C. McCormack,Fed. Proc. 44, 1853 (1985).
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Paper No. 10743 of the Journal Series of the NC Agricultural Research Service, Raleigh, NC 27695-7601. The use of trade names implies neither endorsement of the products named nor criticism of similar products not mentioned by the NCARS.
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Petro, A., Hill, C.H. Response of hepatic metallothionein to iron administration. Biol Trace Elem Res 14, 255–263 (1987). https://doi.org/10.1007/BF02795692
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DOI: https://doi.org/10.1007/BF02795692