Biological Trace Element Research

, Volume 14, Issue 1–2, pp 127–141 | Cite as

Uptake and turnover of65Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions

  • Jan Wensink
  • Clement H. Paays
  • Cornelis J. A. van den Hamer


After a single injection,65Zn is slowly taken up by the brain of the rat to a maximum after 7 d, followed by a turnover phase, with a half-time of about 3 wk. In the brain of rats on a zinc-deficient diet, the65Zn content in the brain continued to increase up to 30 d after the injection.

The uptake and turnover phases in six different subcellular fractions of the brain showed a pattern similar to that of the whole brain in both the control and zinc-deficient rats. There was no internal redistribution of65Zn in the brain under conditions of progressive zinc deficiency.

The results are discussed in a model for zinc homeostasis in the brain.

Index Entries

65Zn, metabolism in brain subcellular fractions zinc deficiency, effect on metabolism of65Zn in brain subcellular fractions brain, metabolism of65Zn in subcellular fractions 


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Copyright information

© The Humana Press Inc 1987

Authors and Affiliations

  • Jan Wensink
    • 1
  • Clement H. Paays
    • 1
  • Cornelis J. A. van den Hamer
    • 1
  1. 1.Department of RadiochemistryInteruniversity Reactor InstituteDelftThe Netherlands

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