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Uptake and turnover of65Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions

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Abstract

After a single injection,65Zn is slowly taken up by the brain of the rat to a maximum after 7 d, followed by a turnover phase, with a half-time of about 3 wk. In the brain of rats on a zinc-deficient diet, the65Zn content in the brain continued to increase up to 30 d after the injection.

The uptake and turnover phases in six different subcellular fractions of the brain showed a pattern similar to that of the whole brain in both the control and zinc-deficient rats. There was no internal redistribution of65Zn in the brain under conditions of progressive zinc deficiency.

The results are discussed in a model for zinc homeostasis in the brain.

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Wensink, J., Paays, C.H. & van den Hamer, C.J.A. Uptake and turnover of65Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions. Biol Trace Elem Res 14, 127–141 (1987). https://doi.org/10.1007/BF02795603

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  • DOI: https://doi.org/10.1007/BF02795603

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