Biological Trace Element Research

, Volume 10, Issue 1, pp 19–24 | Cite as

Effects of CuDIPS and tween 80 on SJL/J tumorigenesis

  • Charles G. Crispens
  • Philip S. Porter
  • John R. J. Sorenson
Original Articles


Plasma copper and zinc levels were measured in SJL/J mice, an inbred strain characterized by a high, spontaneous incidence of reticulum cell sarcoma (RCS). The changes with age in mean concentrations of these metals were consistent with a physiological response that is required for remission of neoplasia. Treatment of SJL/J mice with a copper complex, Cu(II)(3,4-diisopropylsalicylate)2 (Cu 3,5-DIPS), dissolved in a 10% Tween 80-saline solution revealed a decrease in survival and decline in the incidence of RCS at 52 wk of age. The toxic effects of Cu 3,5-DIPS therapy appeared to be related to the intraperitoneal route of administration and to extracellular deposition of collagen. The inhibitory effect on tumor development was not related to Cu 3,5-DIPS. Rather, Tween 80 was found to be the factor of importance.

Index Entries

Copper copper complex toxicity reticulum cell sarcoma SJL/J mice Tween 80 zinc 


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Copyright information

© The Humana Press Inc 1986

Authors and Affiliations

  • Charles G. Crispens
    • 1
  • Philip S. Porter
    • 2
  • John R. J. Sorenson
    • 2
  1. 1.Department of BiologyUniversity of Alabama at BirminghamBirmingham
  2. 2.Department of Medicinal Chemistry, College of PharmacyUniversity of Arkansas for Medical SciencesLittle Rock

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