Biological Trace Element Research

, Volume 52, Issue 2, pp 171–179 | Cite as

Tissue manganese levels and liver pyruvate carboxylase activity in magnesium-deficient rats

  • Mieko Kimura
  • Mayumi Ujihara
  • Katsuhiko Yokoi
Original Articles


To investigate the manganese status in magnesium deficiency, 40 male Wistar rats, 3 wk old, were divided into two groups and fed a magnesium deficient diet or a normal synthetic diet for 2 wk. Dietary magnesium depletion decreased magnesium levels in brain, spinal cord, lung, spleen, kidney, testis, bone, blood, and plasma, while it elevated the magnesium level in liver. In magnesium-depleted rats, calcium concentration was increased in lung, liver, spleen, kidney, and testis, while it was decreased in tibia. In magnesium-depleted rats, manganese concentration was decreased in plasma and all tissues except adrenal glands and blood. Dietary magnesium depletion diminished pyruvate carboxylase (EC activity in the crude mitochondrial fraction of liver. Positive correlation was found between the liver manganese concentration and the pyruvate carboxylase activity. In the magnesium-depleted rats, glucose was decreased while plasma lipids (triglycerides, phospholipids, and total cholesterol) were increased. These results suggest that dietary magnesium deficiency changes manganese metabolism in rats.

Index Entries

Managenese deficiency magnesium deficiency rats pyruvate carboxylase activity in liver mitochondria 


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Copyright information

© Humana Press Inc 1996

Authors and Affiliations

  • Mieko Kimura
    • 1
  • Mayumi Ujihara
    • 1
  • Katsuhiko Yokoi
    • 1
  1. 1.Department of Social Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan

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