Abstract
Cadmium compounds are widely spread in the environment. Animal exposure to cadmium compounds occurs mainly through foods or drinks contaminated by this metal. Cadmium has been shown to produce several negative effects on the gastrointestinal tract such as inhibition on sugars and amino acids absorption. The aim of the present work was to study the inhibitory characteristics of cadmium on L-threonine intestinal absorption in rabbits in order to understand about this malabsorption of nutrients. Our results show that L-thereonine tissue accumulation as well as mucosal to serosal transepithelial fluxes are decreased in a dose-dependent manner in rabbit jejunum. Amino acid diffusion across the intestinal epithelium was not affected by cadmium. A noncompetitive mechanism and a partial reversion by dithioerythritol (thiol groups protector) is described for this inhibition.
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O. F. Andersen, J. B. Nielsen, and P. Svendsen,Toxicology 48, 225–236 (1988).
O. F. Andersen, J. B. Nielsen, and P. Svendsen,Toxicology 52, 65–79 (1988).
C. E. Bevan and E. C. Foulkes,Toxicology 54, 297–309 (1989).
L. Friberg, M. Piscator, G. F. Nordberg, and T. Kjellstroöm,Cadmium in the Environment, 2nd ed., CRC, Cleveland, OH (1974).
S. Jamall, M. Naik, J. J. Sprowls, and L. D. Trombetta,Toxicol. Appl. Pharmacol. 9(5), 339–345 (1989).
G. O'Brien and L. J. King,Toxicology 56, 87–94 (1989).
H. Ohta and M. G. Cherian,Toxicol. Appl. Pharmacol. 107, 63–72 (1991).
D. L. Hamilton and L. S. Valberg,Am. J. Physiol. 227, 1033–1037 (1974).
W. J. R. Moore, J. F. Stara, and W. C. Crocker,Environ. Res. 6, 159–164 (1973).
M. W. Neathery and W. J. Miller,J. Dairy. Sci. 58, 1767–1781 (1975).
D. Kello, N. Sugawara, C. Voner, and E. C. Foulkes,Toxicology 14, 199–208 (1979).
L. Lerner, P. A. Sattelmeyer, P. A. Janicky, and J. S. P. Estes,Comp. Biochem. Physiol. 56, 171–177 (1977).
E. C. Foulkes,Biol. Trace Elem. Res. 21, 195–200 (1989).
M. J. Rodriguez-Yoldi and F. Ponz,Rev. esp. Fisiol. 42(3), 359–364 (1986).
M. J. Rodriguez-Yoldi, A. Lugea, A. Barber, M. Lluch, and F. Ponz,Rev. esp. Fisiol. 45 (suppl), 207–214 (1989).
M. C. Rodriguez-Yoldi, J. E. Mesonero, and M. J. Rodriguez-Yoldi,J. Vet. Med. serie A 39, 687–695 (1992).
M. C. Rodriguez-Yoldi, J. E. Mesonero, and M. J. Rodriguez-Yoldi,Biol. Trace Elem. Res. 37, 269–279 (1993).
J. E. Mesonero, M. C. Rodriguez-Yoldi, and M. J. Rodriguez-Yoldi,Res. Vet. Sci. 54, 189–194 (1993).
J. E. Mesonero, M. C. Rodriguez-Yoldi, and M. J. Rodriguez-Yoldi,Biol. Trace Elem. Res. 38, 217–225 (1993).
J. E. Mesonero, M. C. Rodriguez-Yoldi, and M. J. Rodriguez-Yoldi,Reprod. Nutr. Dev. 34, 115–123 (1994).
F. Lebas, Nutrition of rabbits, inFeeding of Non-Rumiant Livestock, translated by J. Wiseman, ed., University of Nothingham School of Agriculture, England, pp. 63–69 (1987).
P. J. Moughan, W. H. Schultze, and W. C. Smith,Anim. Prod. 47, 297–301 (1988).
W. H. Schultze, W. C. Smith, and P. J. Moughan,Anim. Prod. 47, 303–310 (1988).
R. G. D. Steel and J. H. Torrie,Principles and Procedures of Statistics. A Biometrial Approach. McGraw-Hill, New York (1980).
S. Kojima, M. Kiyozumi, T. Honda, T. Shimizu, Y. Moriyama, and E. Sueyoshi,Chem. Pharm. Bull. 34(1), 372–377 (1986).
C. Bevan, E. Kinne-Saffran, E. C. Foulkes, and R. K. H. Kinne,Toxicol. Appl. Pharmacol. 101, 461–469 (1989).
K. R. Kim, H. Y. Lee, C. K. Kim, and Y. S. Park,Toxicol. Appl. Pharmacol. 106, 102–111 (1990).
E. C. Foulkes and S. Blanck,Toxicol. Appl. Pharmacol. 108, 150–156 (1991).
R. K. Tuker and A. Matte,Bull. Environ. Contam. Toxicol. 24, 847–852 (1980).
K. B. Jacobson and J. E. Turner,Toxicology 16, 1–37 (1980).
D. M. Templeton,J. Biol. Chem. 265, 21,764–21,770 (1990).
T. Taguchi and K. Nakamura,J. Toxicol. Environ. Health 9, 401–409 (1982).
F. Tsuruki, S. Moriuchi, and N. Hosoya,J. Nutr. Sci. Vit. 32, 191–204 (1986).
E. C. Foulkes and D. M. McMullen,Am. J. Physiol. 253, G134-G138 (1987).
D. H. Hamer,Annu. Rev. Biochem. 55, 915–951 (1986).
A. Klip, S. Grinstein, and G. Semenza,Biochim. Biophys. Acta 558, 233–245 (1979).
B. R. Stevens, J. D. Kaunitz, and E. M. Wright,Ann. Rev. Physiol. 46, 417–433 (1984).
B. G. Munck,J. Membr. Biol. 83, 1–13 (1985).
J. M. Harig, J. A. Barry, V. M. Rajendran, K. H. Sorgel, and K. Ramaswamy,Am. J. Physiol. 256, G618-G623 (1989).
P. Gunter-Smith, E. Grasset, and S. G. Schultz,J. Membr. Biol. 66, 25–39 (1982).
D. D. Maenz and J. F. Patience,J. Biol. Chem. 267(31), 22,079–22,086 (1992).
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Mesonero, J.E., Yoldi, MC.R. & Yoldi, MJ.R. Inhibition of L-threonine intestinal absorption in rabbits by cadmium. Biol Trace Elem Res 52, 133–142 (1996). https://doi.org/10.1007/BF02789455
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DOI: https://doi.org/10.1007/BF02789455