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Biological Trace Element Research

, Volume 52, Issue 2, pp 133–142 | Cite as

Inhibition of L-threonine intestinal absorption in rabbits by cadmium

  • José Emilio Mesonero
  • María-Carmen Rodriguez Yoldi
  • María-Jesús Rodriguez Yoldi
Original Articles

Abstract

Cadmium compounds are widely spread in the environment. Animal exposure to cadmium compounds occurs mainly through foods or drinks contaminated by this metal. Cadmium has been shown to produce several negative effects on the gastrointestinal tract such as inhibition on sugars and amino acids absorption. The aim of the present work was to study the inhibitory characteristics of cadmium on L-threonine intestinal absorption in rabbits in order to understand about this malabsorption of nutrients. Our results show that L-thereonine tissue accumulation as well as mucosal to serosal transepithelial fluxes are decreased in a dose-dependent manner in rabbit jejunum. Amino acid diffusion across the intestinal epithelium was not affected by cadmium. A noncompetitive mechanism and a partial reversion by dithioerythritol (thiol groups protector) is described for this inhibition.

Index Entries

L-threonine cadmium jejunum intestinal absorption rabbits 

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Copyright information

© Humana Press Inc 1996

Authors and Affiliations

  • José Emilio Mesonero
    • 1
  • María-Carmen Rodriguez Yoldi
    • 1
  • María-Jesús Rodriguez Yoldi
    • 1
  1. 1.Departamento de Farmacología y FisiologíaFacultad de VeterinariaZaragozaSpain

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