Advertisement

Biological Trace Element Research

, Volume 3, Issue 1, pp 7–11 | Cite as

Antibody suppression by zinc and nickel

  • S. Mehrmofakham
  • L. Treagan
Original Articles

Abstract

Rats were treated with zinc chloride and with nickel acetate 2 weeks prior to immunization withE. coli bacteriophageT-1; antibody titers to bacteriophageT-1 were reduced 500–2600-fold in metal-treated rats compared to titers found in untreated control animals. Examination of the effect of metal treatment on lymphocyte blastogenesis revealed a significant reduction in the number of blast cells in the spleens of metal-treated rats.

Index Entries

Zinc, and antibody suppression in rats antibody, suppression by zinc and nickel in rats blast cell transformation, suppression by zinc and nickel immune suppression, of antibodies by nickel and zinc nickel, and antibody suppression in rats 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    L. Treagan,Biol. Trace Elem. Res. 1, 141 (1979).Google Scholar
  2. 2.
    R. H. Jones, R. L. Williams, and A. M. Jones,Proc. Soc. Exptl. Biol. Med. 137, 1231 (1971).Google Scholar
  3. 3.
    J. A. Graham, F. J. Miller, M. J. Daniels, E. A. Payne, and D. E. Gardner,Envir. Res. 16, 77 (1973).CrossRefGoogle Scholar
  4. 4.
    R. Figoni and L. Treagan,Res. Comm. Chem. Path. Pharmac. 11, 335 (1975).Google Scholar
  5. 5.
    K. M. Rao, S. A. Schwartz, and R. A. Good,Cell. Immunol. 42, 270 (1979).PubMedCrossRefGoogle Scholar
  6. 6.
    H. W. Schlipkoter, L. Ghelerter, and M. Sonderfeld,Zbl. Bakt. Hyg. Orig. B. 163, 417 (1976).Google Scholar
  7. 7.
    B. D. Davis, R. Dulbecco, H. N. Eisen, H. S. Ginsberg, W. B. Wood, Jr., and M. McCarty,Microbiology, Harper and Row, Hagerstown, Md., 1973, pp. 1042–11044.Google Scholar
  8. 8.
    M. Hollander and D. A. Wolfe,Non-parameter Statistical Methods, Wiley, New York., N.Y. 1973, pp. 67–68.Google Scholar
  9. 9.
    J. A. Graham, D. E. Gardner, F. J. Miller, M. J. Daniels, and D. L. Coffin,Envir. Health Pers. 12, 109 (1975).CrossRefGoogle Scholar
  10. 10.
    L. Treagan and A. Furst,Res. Comm. Chem. Path. Pharmac. 1, 395 (1970).Google Scholar
  11. 11.
    N. A. Berger and A. M. Skinner,J. Cell Biol. 61, 45 (1974).CrossRefGoogle Scholar
  12. 12.
    Y. A. Shin, J. M. Heim, and L. Eichorn,Bioinorgan. Chem. 1, 149 (1972).CrossRefGoogle Scholar

Copyright information

© The Humana Press Inc 1981

Authors and Affiliations

  • S. Mehrmofakham
    • 1
  • L. Treagan
    • 1
  1. 1.Department of BiologyUniversity of San FranciscoSan Francisco

Personalised recommendations