Biological Trace Element Research

, Volume 3, Issue 1, pp 7–11 | Cite as

Antibody suppression by zinc and nickel

  • S. Mehrmofakham
  • L. Treagan
Original Articles


Rats were treated with zinc chloride and with nickel acetate 2 weeks prior to immunization withE. coli bacteriophageT-1; antibody titers to bacteriophageT-1 were reduced 500–2600-fold in metal-treated rats compared to titers found in untreated control animals. Examination of the effect of metal treatment on lymphocyte blastogenesis revealed a significant reduction in the number of blast cells in the spleens of metal-treated rats.

Index Entries

Zinc, and antibody suppression in rats antibody, suppression by zinc and nickel in rats blast cell transformation, suppression by zinc and nickel immune suppression, of antibodies by nickel and zinc nickel, and antibody suppression in rats 


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Copyright information

© The Humana Press Inc 1981

Authors and Affiliations

  • S. Mehrmofakham
    • 1
  • L. Treagan
    • 1
  1. 1.Department of BiologyUniversity of San FranciscoSan Francisco

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