Advertisement

Effect of Cuprofilin on experimental atherosclerosis

  • Mariana Vlad
  • E. Bordas
  • Elena Caseanu
  • G. Uza
  • Emilia Creteanu
  • C. Polinicenco
Article

Abstract

The effect of Cuprofilin, a newly synthesized C.(II)-chlorophyll complex, was assessed in rats with experimental atherosclerosis. The study was focused on changes in serum cholesterol, lipids, and triglycerides concentration as well as on serum and abdominal aorta Cu and Zn values. It has been ascertained that after 90 d in animals fed a rich lipid diet there was a statistically significant increase in serum cholesterol, triglycerides, and lipid concentration (p < 0.01). A significant augmentation of serum Cu values (p < 0.01) accompanied by a marked lowering of the same element in abdominal aorta (p < 0.01) was also found, as compared to the results registered in the control group. However, Cuprofilin, administered for 90 d in the group of animals with experimental atherosclerosis, significantly decreased the serum cholesterol, triglycerides, and serum lipid values (p < 0.01), increased copper content in aortic tissue (p < 0.01) and lowered serum copper concentration (p < 0.01) as compared to the untreated group. Moreover, in the aorta of administered animals the lipid infiltration has been demonstrated to be significantly diminished vs the untreated group.

Index Entries

Serum cholesterol triglyceride and total lipids serum Cu and Zn tissue Cu and Zn concentration Cuprofilin experimental atherosclerosis 

References

  1. 1.
    M. Vlad, E. Bordas, Rodica Tomus, Doina Sava, and Ecaterina Farcas,Biol. Tr. Elem. Res. 38,1, 47–54 (1993).CrossRefGoogle Scholar
  2. 2.
    M. Cucuianu, T. A. Popescu, A. Opincaru, and St. Haragus,Clin. Chim. Acta 59, 19 (1975).PubMedCrossRefGoogle Scholar
  3. 3.
    K. G. Allen and L. M. Klevay,Atherosclerosis 29, 81–93 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    H. A. Hunsacker, M. Morita, and K. G. Allen,Atherosclerosis 51, 1–19 (1984).CrossRefGoogle Scholar
  5. 5.
    J. T. Saari,Proc. Soc. Exp. Biol. Med. 200, 19–24 (1992).PubMedGoogle Scholar
  6. 6.
    L. M. Klevay,Am. J. Clin. Nutr. 26, 1060–1068 (1973).PubMedGoogle Scholar
  7. 7.
    L. M. Klevay,Metabolism 33, 1112–1118 (1984).PubMedCrossRefGoogle Scholar
  8. 8.
    Y. Thuiller-Juteau, M. C. Jaudon, J. P. Clavel, J. Delattre, and A. Galli,Pathol. Biol. 35, 387–390 (1987).Google Scholar
  9. 9.
    R. Masironi, in,Hardness of Drinking Water and Public Health, Commission of the European Communities, Pergamon, Oxford, pp. 411–440 (1976).Google Scholar
  10. 10.
    A. N. Howard, G. A. Greshak, and R. Sham,J. Tr. Elem. Exp. Med. 2, 134 (1989).Google Scholar
  11. 11.
    L. M. Klevay,Am. J. Clin. Nutr. 28, 764–774 (1975).PubMedGoogle Scholar
  12. 12.
    L. M. Klevay,Ann. NY Acad. Sci. 355, 140–151 (1980).PubMedCrossRefGoogle Scholar
  13. 13.
    L. M. Klevay,Biol. Tr. Elem. Res. 5, 245–255 (1983).CrossRefGoogle Scholar
  14. 14.
    L. M. Klevay,Med. Hypotheses 24, 111–119 (1987).PubMedCrossRefGoogle Scholar
  15. 15.
    N. Anitschkow, and S. Chalatow,Zentralbl f Allgemaine Pathol. Anal. 14, 1–9 (1913).Google Scholar
  16. 16.
    A. S. Truswell,Am. Clin. Nutr. 31, 977–989 (1978).Google Scholar
  17. 17.
    D. C. K. Roberts, M. W. Huff, and K. K. Carroll,Lipids 14, 566–571 (1979).PubMedCrossRefGoogle Scholar
  18. 18.
    J. R. J. Sorenson,Antiarthritic, Antiulcer and Analgesic Activites of Copper Complexes, Second meeting of the International Society for Trace Element, Tokyo, p. 39 (1989).Google Scholar
  19. 19.
    C. E. Weber,Med. Hypothesis 15, 333 (1984).CrossRefGoogle Scholar
  20. 20.
    T. P. Carr and K. Y. Lei,Metabolism 39, 518–524 (1990).PubMedCrossRefGoogle Scholar
  21. 21.
    J. R. J. Sorenson, in,Inflammatory Diseases and Copper J. R. J. Sorenson, Humana Press, Clifton, New Jersey, pp. 289 (1982).Google Scholar
  22. 22.
    J. R. J. Sorenson,J. Med. Chem. 19, 135–148 (1976).PubMedCrossRefGoogle Scholar
  23. 23.
    J. R. J. Sorenson and S. Hangarter,Inflammation 2, 217–238 (1977).PubMedCrossRefGoogle Scholar
  24. 24.
    S. Okuyama, S. Hashimoto, H. Aihara, W. M. Willingham, and J. R. J. Sorenson,Agents and Actions 21, 130–144 (1987).PubMedCrossRefGoogle Scholar
  25. 25.
    G. Uza, Mariana Vlad, T. Dobosi, and Lavinia Comes,Rev. Roum. Med. Int. 31, 1, 33–37 (1993).Google Scholar

Copyright information

© Humana Press Inc. 1995

Authors and Affiliations

  • Mariana Vlad
    • 1
  • E. Bordas
    • 1
  • Elena Caseanu
    • 1
  • G. Uza
    • 2
  • Emilia Creteanu
    • 1
  • C. Polinicenco
    • 3
  1. 1.Institute of Public Health and Medical ResearchRomania
  2. 2.Departmental Policlinic IIRomania
  3. 3.University of Medicine and PharmacyClujNapocaRomania

Personalised recommendations