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International Journal of Pancreatology

, Volume 24, Issue 2, pp 103–109 | Cite as

Effects of the polyacetate esters of nutrient and nonnutrient monosaccharides on45Calcium efflux and insulin release from perifused rat pancreatic islets

  • Karim Louchami
  • Marcel M. Kadiata
  • Hassan Jijakli
  • Willy J. Malaisse
Original Articles
  • 32 Downloads

Summary

Conclusion

The polyacetate esters of selected nonnutrient monosaccharides represent potential tools for either stimulation of insulin release in noninsulin-dependent diabetes or inhibition of insulin secretion in hyperinsulinemic syndromes.

Background

The polyacetate esters of several monosaccharides were recently shown to display greater nutritional value or biological efficiency than the corresponding unesterified carbohydrates.

Methods

The effects of seven polyacetate esters of monosaccharides, all tested at a 1.7-mM concentration on both45Ca efflux and insulin release were investigated in prelabeled rat pancreatic islets perifused in the presence of 10.0 mM succinic acid dimethyl ester.

Results

Both α-D-glucose penta-acetate and, to a lesser extent, β-L-glucose penta-acetate stimulated insulin release. Inversely, α-D-galactose penta-acetate, but not β-D-galactose penta-acetate inhibited insulin secretion evoked by succinic acid dimethyl ester. Esters of carbohydrates which are inhibitors ofD-glucose metabolism, such asD-mannoheptulose hexa-acetate and the two anomers of 2-deoxy-D-glucose tetra-acetate. Only also enhanced insulin output, with a preference for the α-anomer of 2-deoxy-D-glucose tetra-acetate. Only those esters with positive insulinotropic action augmented45Ca efflux from the prelabeled islets.

Key Words

D- andL-glucose penta-acetate D-galactose penta-acetate D-mannoheptulose hexa-acetate 2-deoxy-D-glucose tetra-acetate pancreatic islets insulin secretion 45Ca efflux 

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Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Karim Louchami
    • 1
  • Marcel M. Kadiata
    • 1
  • Hassan Jijakli
    • 1
  • Willy J. Malaisse
    • 1
  1. 1.Laboratory of Experimental MedicineBrussels Free UniversityBrusselsBelgium

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