International Journal of Pancreatology

, Volume 3, Issue 4, pp 229–240 | Cite as

Laboratory tests in the diagnosis of the chronic pancreatic diseases

Part 6. Differentiation between chronic pancreatitis and pancreatic cancer
  • E. J. S. Boyd
  • H. Rinderknecht
  • K. G. Wormsley


Pancreatitis Pancreatic Cancer Acute Pancreatitis Chronic Pancreatitis Serum Ferritin 
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  1. 1.
    Dreiling DA. Pancreatic secretory testing in 1974. Gut 1975; 16: 653–657.PubMedCrossRefGoogle Scholar
  2. 2.
    Masson PL, Heremans JF, Dive C. An iron-binding protein common to many external secretions. Clin Chim Acta 1966; 14: 735–739.CrossRefGoogle Scholar
  3. 3.
    Multigner L, Figarella C, Sarles H. Diagnosis of chronic pancreatitis by measurement of lactoferrin in duodenal juice. Gut 1981; 22: 350–354.PubMedCrossRefGoogle Scholar
  4. 4.
    Colomb E, Estevenon JP, Figarella C, Guy O, Sarles H. Characterisation of an additional protein in pancreatic juice of men with chronic calcifying pancreatitis. Identification with lactoferrin. Biochim Biophys Acta 1974; 342: 306–312.PubMedGoogle Scholar
  5. 5.
    Fedail SS, Harvey RF, Salmon P, Brown P,. Trypsin and lactoferrin levels in pure pancreatic juice in patients with pancreatic disease. Gut 1979; 20: 983–986.PubMedCrossRefGoogle Scholar
  6. 6.
    Toskes PP. Lactoferrin levels in duodenal secretions of patients with chronic pancreatitis. Gastroenterol 1982; 82: 157.Google Scholar
  7. 7.
    Estevenson JP, Figarella C. A non-competitive enzyme immunoassay of human lactoferrin in biological fluids. Clin Chim Acta 1983; 129: 311–318.CrossRefGoogle Scholar
  8. 8.
    Multigner L, Figarella C, Sahel J, Sarles H. Lactoferrin and albumin in human pancreatic juice: a valuable test for diagnosis of pancreatic disease. Dig Dis Sci 1980; 25: 173–178.PubMedCrossRefGoogle Scholar
  9. 9.
    Fedail SS, Harvey RF, Salmon PR, Read AE. Radioimmunoassay of lactoferrin pancreatic juice as a test for pancreatic disease. Lancet 1978; 1: 181–182.PubMedCrossRefGoogle Scholar
  10. 10.
    Gaia E, Figarella C, Piantino P, et al. Duodenal lactoferrin in patients with chronic pancreatitis and gastrointestinal diseases. Digestion 1985; 32: 229–237.PubMedCrossRefGoogle Scholar
  11. 11.
    Nicolai JJ, Teunen A, Zuyderhout F, Hoek F, Tytgat GNJ. Lactoferrin in pure pancreatic juice. Scand J Gastroenterol 1984; 19: 765–769.PubMedGoogle Scholar
  12. 12.
    Anagnostides AA, Cox TM, Adrian TE, et al. Pancreatic exocrine and endocrine responses in chronic pancreatitis. Am J Gastroenterol 1984; 79: 206–212.PubMedGoogle Scholar
  13. 13.
    Dürr GHK, Amouric M, Bode C, Bode JC, Sarles H, Figarella C. Salivary secretion in chronic pancreatitis with special reference to albumin and lactoferrin. Digestion 1982; 24: 87–93.PubMedGoogle Scholar
  14. 14.
    Benini L, Harvey RF, Vantini I, et al. Lactoferrin concentration in the parotid saliva of patients with chronic pancreatitis. Digestion 1983; 28: 77–81.PubMedCrossRefGoogle Scholar
  15. 15.
    MacKie CR, Cooper MJ, Lewis MH, Moosa AR. Non-operative differentiation between pancreatic cancer and chronic pancreatitis. Ann Surg 1979; 198: 480–487.Google Scholar
  16. 16.
    Podolsky DK, McPhee MS, Alpert E, Warshaw AL, Isselbacher KJ. Galactosyltransferase isoenzyme II in the detection of pancreatic cancer: comparison with radiologic, endoscopic and serologic tests. New Eng J Med 1981; 304: 1313–1318.PubMedCrossRefGoogle Scholar
  17. 17.
    Fitzgerald PJ, Firther JG, Watson RC, et al. The value of diagnostic aids in detecting pancreas cancer. Cancer 1978; 73: 457–461.Google Scholar
  18. 18.
    Wood RAB, Moosa AR. The prospective evaluation of tumour-associated antigens for the early diagnosis of pancreatic cancer. Br J Surg 1977; 64: 718–720.PubMedCrossRefGoogle Scholar
  19. 19.
    Fabris C, Farini R, Piccoli A, et al. CEA and ferritin in chronic pancreatic disease: a comparative evaluation. Hepatogastroenterol 1985; 32: 146–148.Google Scholar
  20. 20.
    Schmiegel WH, Kreiker C, Eberl W, et al. Monoclonal antibody defines CA19-9 in pancreatic juices and sera. Gut 1986; 26: 456–460.CrossRefGoogle Scholar
  21. 21.
    Tatsuta M, Yamamura H, Noguchi S, Ichii M, Iisgi H, Okuda S. Values of serum carcinoembryonic antigen and elastase 1 in diagnosis of pancreatic carcinoma. Gut 1984; 25: 1347–1351.PubMedCrossRefGoogle Scholar
  22. 22.
    DiMagno EP, Malagelada J-R, Moertel CG, Go VLW. Prospective evaluation of the pancreatic secretion of immunoreactive carcinoembryonic antigen, enzyme and bicarbonate in patients suspected of having pancreatic cancer. Gastroenterol 1977; 73: 457–461.Google Scholar
  23. 23.
    Farini R, Nitti D, Del Favero G, et al. CEA concentration and cytology in duodenal fluid collected during the secretin-pancreozymin test. Hepatogastroenterol 1980; 27: 213–216.Google Scholar
  24. 24.
    Rolny P, Elwing H, Nilsson L-Å. The CEA concentration in duodenal fluid in patients with pancreatic disease. Scand J Gastroenterol 1977; 12: 759–763.PubMedCrossRefGoogle Scholar
  25. 25.
    Sharma MP, Gregg JA, Loewenstein MS, McCabe RP, Zamcheck N. Carcinoembryonic antigen activity in pancreatic juice of patients with pancreatic carcinoma and pancreatitis. Cancer 1976; 38: 2457–2461.PubMedCrossRefGoogle Scholar
  26. 26.
    Nishida K, Yoshikawa T, Kondo M, Thiele H-G. Immunological diagnosis of pancreatic cancer by assaying carcinoembryonic antigen (CEA) in pure pancreatic juice. Hepatogastroenterol 1980; 27: 488–494.Google Scholar
  27. 27.
    Tatsuta M, Yamamura H, Yamamoto R, Okano Y, Morii T, Okuda S, Tamura H. Significance of carcinoembryonic antigen levels and cytology of pure pancreatic juice in diagnosis of pancreatic cancer. Cancer 1985; 53: 1880–1885.Google Scholar
  28. 28.
    Tatsuta M, Yamamura H, Yamumoto R, Moru T, Okuda S, Tamura H. Carcinoembryonic antigen in the bile in patients with pancreatic and biliary cancer. Correlation with cytology and percutaneous transhepatic cholangiography. Cancer 1982; 50: 2903–2909.PubMedCrossRefGoogle Scholar
  29. 29.
    Gelder FB, Reese CJ, Moosa AR, Hall T, Hunter R. Purification, partial characterisation, and clinical evaluation of a pancreatic oncofoetal antigen. Cancer Research 1978; 38: 313–324.PubMedGoogle Scholar
  30. 30.
    Nishida K, Kondo M, Jessen K, Classen M. Diagnosis of pancreatic cancer by pancreatic oncofetal antigen (POA) assay of pure pancreatic juice. Hepatogastroenterol 1981; 28: 102–105.Google Scholar
  31. 31.
    Schmiegel WH, Eberl W, Kreiker C, et al. Multiparametric tumour marker (CA19-9, CEA, AFP, POA) analyses of pancreatic juices and sera in pancreatic disease. Hepatogastroenterol 1985; 32: 141–145.Google Scholar
  32. 32.
    Del Vilano BL, Brennan S, Brock P, et al. Radioimmunometric assay for monoclonal antibody defined tumour maker CA19-9. Clin Chem 1983; 29: 549–552.Google Scholar
  33. 33.
    Haglund C, Lindgren J, Roberts PJ, Nordling S. Gastrointestinal cancer-associated antigen CA19-9 in histological specimens of pancreatic tumours and pancreatitis. Br J Cancer 1986; 53: 189–195.PubMedGoogle Scholar
  34. 34.
    Del Favero G, Fabris C, Plebani M, et al. CA19-9 and carcinoembryonic antigen in pancreatic cancer diagnosis. Cancer 1986; 57: 1576–1579.PubMedCrossRefGoogle Scholar
  35. 35.
    Haglund C, Roberts PJ, Kuusela P, Scheinin TM, Mäkelä O, Jalanko H. Evaluation of CA19-9 as a serum tumour marker in pancreatic cancer. Br J Cancer 1986; 53: 197–202.PubMedGoogle Scholar
  36. 36.
    Sakahara H, Endo K, Nakajima K, et al. Serum CA19-9 concentrations and computed tomography findings in patients with pancreatic carcinoma. Cancer 1986; 57: 1324–1326.PubMedCrossRefGoogle Scholar
  37. 37.
    Steinberg WM, Gelfand R, Anderson KK. Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen in detecting cancer of the pancreas. Gastroenterol 1986; 90: 343–349.Google Scholar
  38. 38.
    Tatsuta M, Yamamura H, Ilshi H, et al. Values of CA19-9 in the serum, pure pancreatic juice, and aspirated material in the diagnosis of malignant pancreatic tumour. Cancer 1985; 56: 2669–2673.PubMedCrossRefGoogle Scholar
  39. 39.
    Safi F, Büchler M, Schenkluhn B, Berger HG. Diagnostic significance of the tumour marker CA19-9 in carcinoma of the pancreas. Dtsch Med Woch 1984; 109:1869–1873.CrossRefGoogle Scholar
  40. 40.
    Safi F, Berger HG, Bittner R, Büchler M, Krantzberger W. Ca19-9 and pancreatic adenocarcinoma. Cancer 1986; 57: 779–783.PubMedCrossRefGoogle Scholar
  41. 41.
    Farini R, Fabris C, Bonvivini R, et al. CA19-9 in the differential diagnosis between pancreatic cancer and chronic pancreatitis. Eur J Clin Oncol 1985; 21: 429–432.CrossRefGoogle Scholar
  42. 42.
    Wang T-H, Lin J-T, Chen D-S, Sheu J-C, Sung J-L. Non-invasive diagnosis of advanced pancreatic cancer by real-time ultrasonography, carcinoembryonic antigen, and carbohydrate antigen 19-9. Pancreas 1986; 1: 219–223.PubMedCrossRefGoogle Scholar
  43. 43.
    Malesci A, Tommasini MA, Bonato C, Bocchia P, et al. Determination of CA19-9 antigen in serum and pancreatic juice for differential diagnosis of pancreatic adenocarcinoma from chronic pancreatitis. Gastroenterol 1987; 92: 60–67.Google Scholar
  44. 44.
    Habib NA, Hershman MJ, Haberland F, Papp L, Wood CB, Williamson RCN. The use of CA-50 radioimmunoassay in differentiating benign and malignant pancreatic disease. Br J Cancer 1986; 53: 697–699.PubMedGoogle Scholar
  45. 45.
    Warshaw AL, Lee K-H, Wood WC, Cohen AM. Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer. Am J Surg 1980; 139: 27–32.PubMedCrossRefGoogle Scholar
  46. 46.
    Abramson SB, Rinderknecht H, Renner IG, Ribonuclease C and pancreatic secretory proteins in the peripheral circulation before and after pancreatectomy for pancreatic cancer. Dig Dis Sci 1982; 27: 889–896.PubMedCrossRefGoogle Scholar
  47. 47.
    Panucci A, Fabris C, Del Favero G, et al. Tissue polypeptide antigen (TPA) in pancreatic cancer diagnosis. Br J Cancer 1985; 52: 801–803.PubMedGoogle Scholar
  48. 48.
    Panucci A, Fabris C, Del Favero G, et al. Is tissue polypeptide antigen more accurate than serum CEA in diagnosing pancreatic cancer? J Clin Pathol 1986; 39: 75–77.PubMedCrossRefGoogle Scholar
  49. 49.
    Niitsu Y, Kohgo Y, Yokata M, Urushizaki I. Radioimmunoassay of serum ferritin in the diagnosis of pancreatic cancer. Ann N Y Acad Sci 1975; 259: 450–452.PubMedCrossRefGoogle Scholar
  50. 50.
    Nitti D, Fabris C, Del Favero G et al. Serum ferritin in pancreatic disease. An accurate test of malignancy? Digestion 1982; 25: 258–262.PubMedGoogle Scholar
  51. 51.
    Fabris C, Farini R, Del Favero G, et al. Combined evaluation of serum ribonuclease and ferritin: any advantages in pancreatic cancer diagnosis? Oncol 1984; 41: 393–395.Google Scholar
  52. 52.
    Mahvi Meyers WC, Bast RC, Seigler HF, Metzgar RS. Carcinoma of the pancreas. Therapeutic efficacy as defined by a serodiagnostic test utilizing a monoclonal antibody. Ann Surg 1985; 202: 440–444.CrossRefGoogle Scholar
  53. 53.
    Iishi H, Yamamura H, Tatsuta M, Okuda S, Kitamura T. Value of ultrasonographic examination combined with measurement of serum tumor markers in the diagnosis of pancreatic cancer of less than 3 cm diameter. Cancer 1986; 57: 1947–1951.PubMedCrossRefGoogle Scholar
  54. 54.
    Satake K, Chung YS, Umeyama K. Serum elastase-1 levels in pancreatic disease. Am J Surg 1982; 144: 239–242.PubMedCrossRefGoogle Scholar
  55. 55.
    Hamano H, Hayakawa T, Kondo T. Serum immunoreactive elastase in diagnosis of pancreatic cancer. A sensitive marker for pancreatic cancer. Dig Dis Sci 1987; 32: 50–56.PubMedCrossRefGoogle Scholar
  56. 56.
    Robles-Diaz G, Diaz V, Mendez JP, Wolpert E. Second International Meeting of Pancreatology. Sao Paulo 1986:A47.Google Scholar
  57. 57.
    Nieburgs HE, Dreiling DA, Rubio C, Rusman H. The morphology of cells in duodenal drainage smears. Histological origin and pathological significance. Am J Dig Dis 1967; 7: 489–505.CrossRefGoogle Scholar
  58. 58.
    Goodale RL, Gajl-Peczalska K, Dressel T, Samuelson J. Cytologic studies for the diagnosis of pancreatic cancer. Cancer 1981; 47: 1652–1655.PubMedCrossRefGoogle Scholar
  59. 59.
    Endo Y, Morri T, Tamura H, Okuda S. Cytodiagnosis of pancreatic malignant tumours by aspiration under direct vision using a duodenal fibrescope. Gastroenterol 1974; 67: 944–951.Google Scholar
  60. 60.
    MacKie CR, Dhorajiwala J, Blackstone MO, Bowiw J, Moossa AR. Value of new diagnostic aids in relation to the disease process in pancreatic cancer. Lancet 1979; 2: 385–388.PubMedCrossRefGoogle Scholar
  61. 61.
    Mitchell ML, Carney CN. Cytologic criteria for the diagnosis of pancreatic carcinoma. Am J Clin Pathol 1985; 83: 171–176.PubMedGoogle Scholar
  62. 62.
    Hunt DR, Blumgart LH. Pre-operative differentiation between carcinoma of the pancreas and chronic pancreatitis: the contribution of cytology. Endoscopy 1982; 14: 171–173.PubMedCrossRefGoogle Scholar
  63. 63.
    Kameya S, Kuno N, Tasugai T. The diagnosis of pancreas cancer by pancreatic juice cytology. Acta Cytol 1981; 25: 354–360.PubMedGoogle Scholar

Copyright information

© Elsevier Science Publishers B.V. (Biomedical Division) 1988

Authors and Affiliations

  • E. J. S. Boyd
    • 1
    • 2
  • H. Rinderknecht
    • 1
    • 2
  • K. G. Wormsley
    • 1
    • 2
  1. 1.Ninewells Hospital and Medical SchoolDundeeU.K.
  2. 2.Veteran Administration Medical CenterSepulvedaU.S.A.

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