International Journal of Pancreatology

, Volume 24, Issue 3, pp 145–168 | Cite as

Clinical islet cell transplantation

Are we there yet?
  • Lawrence Rosenberg


Diabetes mellitus is perhaps the most devastating chronic disease of all time. A brief history of the evolution of treatment modalities is provided, culminating in the rationale for the physiologic replacement of a functioning β-cell mass by transplantation. Vascularized pancreas transplantation is discussed briefly as an introduction to the transplantation of the isolated islet. A detailed review of the current state of human islet transplantation for the cure of diabetes is then described. Finally, areas for future development are highlighted.

Key Words

Diabetes mellitus islet cell transplantation DCCT immunosuppression 


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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Lawrence Rosenberg
    • 1
    • 2
  1. 1.Department of Surgery and MedicineMcGill UniversityMontrealCanada
  2. 2.Centre for Pancreatic DiseasesMcGill University Health CentreMontrealCanada

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