Abstract
Alexandre et al. have proposed a four-system model of oxidative phosphorylation. The thermodynamic consequences of this model are explored, assuming as a first approximation that these four systems can be treated as a self-contained group. The method can be generalized, in higher approximations, to include further systems and other complications. Respiratory control is considered from the point of view of the model. Self-consistent numerical examples are given to represent mitochondrial activity in state 3 and in state 4.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alexandre, A., Reynafarje, B., and Lehninger, A. L. (1978),Proc. Natl. Acad. Sci. USA 75, 5296.
Hill, T. L. (1979),Proc. Natl. Acad. Sci. USA 76, 232.
Hill, T. L. (1979),Proc. Natl. Acad. Sci. USA 76, 2236.
van Dam, K., and Westerhoff, H. V. (1977), inStructure and Function of Energy-Transducing Membranes (van Dam, K., and van Gelder, B. F., eds.), Elsevier/North-Holland, Amsterdam, pp. 157–167.
Reynafarje, B., and Lehninger, A. L. (1978),Proc. Natl. Acad. Sci. USA 75, 4788.
Hill, T. L. (1977),Free Energy Transduction in Biology, Academic Press, New York.
Lehninger, A. L. (1975),Biochemistry, Worth, New York, 2nd ed., Chapter 19.
Hill, T. L. (1978),J. Theoret. Biol. 75, 391.
Stucki, J. W. (1979), inEnergy Conservation in Biological Membranes (Schäfer, G., and Klingenberg, M., eds.), Springer-Verlag, Berlin, pp. 264–287.
Kedem, O., and Caplan, S. R. (1965),Trans. Faraday Soc. 61, 1897.
Nicholls, D. G. (1974),Eur. J. Biochem.,50, 305.
Rottenberg, H. (1975),J. Bioenerg. 7, 61.
Hill, T. L., and Morales, M. F. (1951),J. Amer. Chem. Soc. 73, 1656.
Mahler, H. R., and Cordes, E. H. (1971),Biological Chemistry, Harper, New York, pp. 21–27.
Alberty, R. A. (1968),J. Biol. Chem. 243, 1337.
Erecińska, M., and Wilson, D. F. (1978),Trends Biochem. Sci. 3, 219.
Wilson, D. F., Owen, C. S., and Holian, A. (1977),Arch. Biochem. Biophys. 182, 749.
Lemasters, J. J., and Sowers, A. E. (1979),Biophys. J. 25, 276a (Abstr.).
Chance, B. (1977),Ann. Rev. Biochem. 46, 967.
Mitchell, P. (1966),Biol. Rev. Camb. Phil. Soc. 41, 445.
Hill, T. L., and Chay, T. R. (1979),Proc. Natl. Acad. Sci. USA 76, 3203.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hill, T.L. Effective coupling of four independent membrane systems in steady-state oxidative phosphorylation. Cell Biophysics 1, 309–329 (1979). https://doi.org/10.1007/BF02788277
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02788277