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Human autoantibodies and their genes

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Abstract

We undertook an analysis of the B cell repertoire at both the germline and somatic levels. To assess the content and organization of the IgH-V and IgK-V loci in SLE, endonuclease-generated polymorphisms were used to characterize individual variations within the human V gene segments. The results are compatible with the conclusion that this disease is not caused by major abnormalities in the structure, size, or organization of the IgV loci. We propose that hyperproduction and lupus-associated autoantibodies arises through a two-stage mechanism whereby a general activation of the multireactive preimmune B-cell repertoire precedes oligoclonal expansion of selected B cell clonotypes.

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Authors and Affiliations

  1. Institut Pasteur, Immunog’en’etique Cellulaire, 28, rue Dr. Roux, 75015, Paris, France

    Moncef Zouali

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  1. Moncef Zouali
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Zouali, M. Human autoantibodies and their genes. Appl Biochem Biotechnol 47, 135–142 (1994). https://doi.org/10.1007/BF02787930

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  • DOI: https://doi.org/10.1007/BF02787930

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