Summary
Conclusion
Pancreatic enzyme supplementation therapy conducted during a 6 moperiod produces better control of diabetes, improvement in nutrition, and overall improvement in quality of life in patients with tropical calculous pancreatitis.
Background
Tropical calculous pancreatitis is characterized by abdominal pain, pancreatic calculi, and diabetes. The diabetes is insulin resistant. The brittle diabetes may be owing to defective glucagon secretion and erratic absorption of nutrients.
Methods
Patients with tropical calculous pancreatitis with diabetes and chronic pancreatitis were studied for fasting and postprandial plasma glucose, glycosylated hemoglobin, serum cholesterol, triglycerides, and calcium, liver function, and plasma C-peptide. All patients were given Creon and evaluated for quality of life.
Results
Clinical parameters of the patients showed considerable improvement at the end of the trial. Abdominal pain, steatorrhea, and sense of well being improved. There was a significant reduction in post-prandial plasma glucose and glycosylated hemoglobin.
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References
Pitchumoni CS. Special problems of tropical pancreatitis.Clin Gastroenterol 1984; 13: 941–959.
Mohan V, Premalatha G. Fibrocalculous pancreatic diabetes.Int J Diabetes 1995; 3: 71–82.
WHO Study Group Report on Diabetes Mellitus. WHO technical report series. No. 727, Geneva: WHO, 1985.
Mohan V, Snehalatha C, Ahmed MR, Madanagopalan N, Chari ST, Jayanthi V, et al. Exocrine pancreatic functions in tropical fibrocalculous pancreatic diabetes.Diabetes Care 1989; 12: 145–147.
Glasbrenner B, Malfertheiner P, Kerner W, Scherbaum WA, Ditschuneit H.Z Gastroenterol 1990; 28: 275–279.
Mohan V, Padma A, Premalatha G, Chari ST, Pitchumoni CS. Fibrocalculous pancreatic diabetes—long term survival analysis.Diabetes Care 1996; 19: 1274–1278.
Pitchumoni CS. Is there an effective non-surgical treatment for pain in chronic pancreatitis. Controversies, dilemmas and dialogues.Am J Gastroenterol 1991; 86: 26–28.
Johnson SA, Toskes TP. Chronic pancreatitis: medical management. Practical gastroenterology.Pancreatic Disease Series 1996: 6–21.
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Mohan, V., Poongothai, S. & Pitchumoni, C.S. Oral pancreatic enzyme therapy in the control of diabetes mellitus in tropical calculous pancreatitis. Int J Pancreatol 24, 19–22 (1998). https://doi.org/10.1007/BF02787526
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DOI: https://doi.org/10.1007/BF02787526