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Medical Oncology

, Volume 15, Issue 4, pp 203–211 | Cite as

Oligoclonal T cells in human cancer

  • Eva Halapi
Review

Abstract

Many solid tumors are characterised by the infiltration of lymphocytes and their presence has been correlated with a more favourable prognosis. These tumor-infiltrating lymphocytes (TIL), have been shown to possess specific cytolytic reactivity towards autologous tumours, thus suggesting that tumour cells may express antigens capable of eliciting an immune response. Expression of such tumour-associated antigens (TAA) in combination with appropriate accessory signals would lead to thein vivo accumulation of T cells with anti-tumour specificity. Analysis of the composition of the specific T-cell receptor (TCR) of TIL could thus provide information on the nature of the antigen(s) recognised by TIL. In this review, different aspects of the presence of clonal T cells in patients with cancer are discussed.

Keywords

tumor-infiltrating lymphocytes T cell receptor tumor-associated antigen melanoma multiple myeloma idiotype 

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Copyright information

© Stockton Press 1998

Authors and Affiliations

  1. 1.deCODE Genetics Inc.ReykjavikIceland

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