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In vitro assessment of the toxicity of metal compounds

II. Mutagenesis

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Abstract

A review of in vitro mutagenesis assessment of metal compounds in mammalian and nonmammalian test systems has been compiled. Prokaryotic assays are ineffective or inconsistent in their detection of most metals as mutagens, with the notable exception of hexavalent chromium. Mammalian assay systems appear to be similarly inappropriate for the screening of metal compounds based upon the limited number of studies that have employed those compounds having known carcinogenic activity. Although of limited value as screening tests for the detection of potentially carcinogenic metal compounds, the well-characterized in vitro mutagenesis systems may prove to be of significant value as a means to elucidate mechanisms of metal genotoxicity.

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Authors and Affiliations

  1. Division of Toxicology, Department of Pharmacology, University of Texas Medical School at Houston, PO Box 20708, 77025, Houston, Texas

    J. Daniel Heck & Max Costa

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  1. J. Daniel Heck
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  2. Max Costa
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Heck, J.D., Costa, M. In vitro assessment of the toxicity of metal compounds. Biol Trace Elem Res 4, 319–330 (1982). https://doi.org/10.1007/BF02786545

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