Advertisement

In vitro assessment of the toxicity of metal compounds

II. Mutagenesis
  • J. Daniel Heck
  • Max Costa
Review

Abstract

A review of in vitro mutagenesis assessment of metal compounds in mammalian and nonmammalian test systems has been compiled. Prokaryotic assays are ineffective or inconsistent in their detection of most metals as mutagens, with the notable exception of hexavalent chromium. Mammalian assay systems appear to be similarly inappropriate for the screening of metal compounds based upon the limited number of studies that have employed those compounds having known carcinogenic activity. Although of limited value as screening tests for the detection of potentially carcinogenic metal compounds, the well-characterized in vitro mutagenesis systems may prove to be of significant value as a means to elucidate mechanisms of metal genotoxicity.

Index Entries

Metals, mutagenesis by arsenic beryllium cadmium chromium cobalt manganese nickel platinum selenium toxicity, of metal compounds mutagenesis, of metals in prokaryotes and eukaryotes prokaryotes, metal mutagenesis studies in eukaryotes, metal mutagenesis studies in 

References

  1. 1.
    F. W. Sunderman, Jr.,Biol. Trace Element Research,1, 63 (1979).Google Scholar
  2. 2.
    F. W. Sunderman, Jr., inEnvironmental Carcinogenesis, P. Emmelot and E. Kriek, eds., Elsevier/North Holland, New York, 1979, pp. 165–192.Google Scholar
  3. 3.
    S. B. Radding and A. Furst, inMolecular Basis of Environmental Toxicity, R. S. Bhatnagar, ed., Ann Arbor Science Publishing, Ann Arbor, Michigan, 1980, pp. 359–372.Google Scholar
  4. 4.
    G. R. Mohn and J. Ellenberger,Arch. Toxicol. 46, 45 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    B. Ames, W. E. Durston, E. Yamasaki, and F. D. Lee,Proc. Natl. Acad. Sci. (USA) 70, 2281 (1973).CrossRefGoogle Scholar
  6. 6.
    J. McCann, E. Choi, E. Yamasaki, and B. N. Ames,Proc. Natl. Acad. Sci. (USA) 72, 5135 (1975).CrossRefGoogle Scholar
  7. 7.
    B. N. Ames,Science 204, 587 (1979).PubMedCrossRefGoogle Scholar
  8. 8.
    E. M. Witkin,Cold Spring Harbor Symp. Quant. Biol. 21, 123 (1956).PubMedGoogle Scholar
  9. 9.
    M. H. L. Green and W. J. Muriel,Mutation Res. 38, 3 (1976).PubMedGoogle Scholar
  10. 10.
    D. J. Brusick, V. F. Simmon, H. S. Rosenkranz, V. A. Ray, and R. S. Stafford,Mutation Res. 76, 169 (1980).PubMedGoogle Scholar
  11. 11.
    T. Kada, Y. Sadaie, and K. Tutikawa,Mutation Res. 16, 165 (1972).PubMedGoogle Scholar
  12. 12.
    H. Nishioka,Mutation Res. 31, 185 (1975).PubMedGoogle Scholar
  13. 13.
    N. Kanematsu and T. Kada,Mutation Res. 53, 207 (1978).Google Scholar
  14. 14.
    N. Kanematsu, M. Hara, and T. Kada,Mutation Res. 77, 109 (1980):PubMedCrossRefGoogle Scholar
  15. 15.
    P. Howard-Flanders,Mutation Res. 86, 307 (1981).PubMedGoogle Scholar
  16. 16.
    E. H. Y. Chu and H. V. Malling,Proc. Natl. Acad. Sci. (USA) 61, 1306 (1968).CrossRefGoogle Scholar
  17. 17.
    D. Clive, W. G. Flamm, M. R. Machesko, and N. J. Bernheim,Mutation Res. 16, 77 (1972).PubMedGoogle Scholar
  18. 18.
    M. A. Sirover,Environ. Health Perspect. 40, 163 (1981).PubMedCrossRefGoogle Scholar
  19. 19.
    G. Pershagen,Environ. Health Perspect. 40, 93 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    M. Kuschner,Environ. Health Perspect. 40, 101 (1981).PubMedCrossRefGoogle Scholar
  21. 21.
    M. Piscator,Environ. Health Perspect. 40, 107 (1981).PubMedCrossRefGoogle Scholar
  22. 22.
    A. Leonard and R. R. Lauwerys,Mutation Res. 76, 227 (1980).PubMedGoogle Scholar
  23. 23.
    T. Norseth,Environ. Health Perspect. 40, 121 (1981).PubMedCrossRefGoogle Scholar
  24. 24.
    J. R. Hatherill,Drug Chem. Toxicol. 4, 185 (1981).PubMedCrossRefGoogle Scholar
  25. 25.
    G. E. Gerber, A. Léonard, and P. Jacquet,Mutation Res. 76, 115 (1980).PubMedGoogle Scholar
  26. 26.
    G. Kazantzis,Environ. Health Perspect. 40, 143 (1981).PubMedCrossRefGoogle Scholar
  27. 27.
    F. W. Sunderman, Jr.,Environ. Health Perspect. 40, 131 (1981).PubMedCrossRefGoogle Scholar
  28. 28.
    Y. Shirasu, M. Moriya, K. Kato, A. Furuhashi, and T. Kada,Mutation Res. 40, 19 (1976).PubMedCrossRefGoogle Scholar
  29. 29.
    G. Löfroth and B. N. Ames,Mutation Res. 53, 65 (1978).Google Scholar
  30. 30.
    T. G. Rossman,Environ. Health Perspect. 40, 189 (1981).PubMedCrossRefGoogle Scholar
  31. 31.
    H. S. Rosenkranz and L. A. Poirier,J. Natl. Cancer Inst. 62, 873 (1979).PubMedGoogle Scholar
  32. 32.
    V. F. Simmon,J. Natl. Cancer Inst. 62, 893 (1979).PubMedGoogle Scholar
  33. 33.
    V. F. Simmon,J. Natl. Cancer Inst. 62, 911 (1979).PubMedGoogle Scholar
  34. 34.
    V. F. Simmon, H. S. Rosenkranz, E. Zeiger, and L. A. Poirier,J. Natl. Cancer Inst. 62, 901 (1979).PubMedGoogle Scholar
  35. 35.
    W. W. Tso and W. P. Fung,Toxicol. Lett. 8, 195 (1981).PubMedCrossRefGoogle Scholar
  36. 36.
    S. De Flora,Carcinogenesis 2, 283 (1980).CrossRefGoogle Scholar
  37. 37.
    J. A. Heddle and W. R. Bruce, inOrigins of Human Cancer, book C. H. H. Hiatt, J. D. Watson, and J. A. Winsten, eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1977, pp. 1549–1557.Google Scholar
  38. 38.
    S. Venitt and L. S. Levy,Nature 250, 493 (1974).PubMedCrossRefGoogle Scholar
  39. 39.
    L. M. Kalinina, G. N. Polukhina, and L. I. Lukasheva,Genetika 13, 1089 (1977).PubMedGoogle Scholar
  40. 40.
    T. H. Corbett, C. Heidelberger, and W. F. Dove,Molec. Pharmacol. 6, 667 (1970).Google Scholar
  41. 41.
    T. Kada and N. Kanematsu,Proc. Japan Acad. 54, 234 (1978).CrossRefGoogle Scholar
  42. 42.
    T. Inoue, Y. Ohta, Y. Sadaie, and T. Kada,Mutation Res. 91, 41 (1981).PubMedCrossRefGoogle Scholar
  43. 43.
    K. W. Jennette,Biol. Trace Element Res. 1, 55 (1979).Google Scholar
  44. 44.
    K. W. Jennette,Environ. Health Perspect. 40, 233 (1981).PubMedCrossRefGoogle Scholar
  45. 45.
    M. Tamaro, E. Banfi, S. Venturini, and C. Monti-Bragadin,XVII Congr. Natl. Soc. Ital. Microbiol., 411 (1975).Google Scholar
  46. 46.
    F. L. Petrilli and S. De Flora,Appl. Environ. Microbiol. 33, 805 (1977).PubMedGoogle Scholar
  47. 47.
    F. L. Petrilli and S. De Flora,Mutation Res. 54, 139 (1978).PubMedGoogle Scholar
  48. 48.
    S. De Flora,Nature 271, 455 (1978).PubMedCrossRefGoogle Scholar
  49. 49.
    F. L. Petrilli and S. De Flora,Mutation Res. 58, 167 (1978).PubMedCrossRefGoogle Scholar
  50. 50.
    S. De Flora, R. Coppola, A. Camoirano, M. A. Battaglia, and C. Bennicelli,Carcinogenesis 1, 583 (1980).PubMedCrossRefGoogle Scholar
  51. 51.
    K. R. Tindall, G. R. Warren, and P. D. Skarr,Mutation Res. 53, 90 (1978).Google Scholar
  52. 52.
    G. Löfroth,Naturwissenschaften 65, 207 (1978).PubMedCrossRefGoogle Scholar
  53. 53.
    E. R. Nestmann, T. I. Matula, G. R. Douglas, K. C. Bora, and D. J. Kowbel,Mutation Res. 66, 357 (1979).PubMedCrossRefGoogle Scholar
  54. 54.
    A. Hedenstedt, D. Jenssen, B. M. Lidesten, C. Ramel, V. Rannug, and R. M. Stern,Scand. J. Work Environ. Health 3, 203 (1977).PubMedGoogle Scholar
  55. 55.
    J. Maxild, M. Andersen, and P. Kiel,Mutation Res. 56, 235 (1978).PubMedGoogle Scholar
  56. 56.
    M. Green, W. Muriel, and B. Bridges,Mutation Res. 38, 33 (1976).PubMedGoogle Scholar
  57. 57.
    K. Nakamuro, K. Yoshikawa, Y. Sayato, and M. Kurata,Mutation Res. 58, 175 (1978).PubMedCrossRefGoogle Scholar
  58. 58.
    D. J. Beck and R. R. Brubaker,Mutation Res. 27, 181 (1975).PubMedCrossRefGoogle Scholar
  59. 59.
    C. Monti-Bragadin, M. Tamaro, and E. Banfi,Chem.-Biol. Interactions 11, 469 (1975).CrossRefGoogle Scholar
  60. 60.
    W. F. Benedict, M. S. Baker, L. Haroun, E. Choi, and B. N. Ames,Cancer Res. 37, 2209 (1977).PubMedGoogle Scholar
  61. 61.
    P. LeCointe, J. Macquet, J. Butour, and C. Paolett,Mutation Res. 48, 139 (1977).PubMedGoogle Scholar
  62. 62.
    D. J. Beck and J. E. Fisch,Mutation Res. 77, 45 (1980).PubMedCrossRefGoogle Scholar
  63. 63.
    K. S. Andersen,Mutation Res. 67, 209 (1979).PubMedCrossRefGoogle Scholar
  64. 64.
    M. Noda, T. Takano, and H. Sakurai,Mutation Res. 66, 175 (1979).PubMedCrossRefGoogle Scholar
  65. 65.
    M. M. Jacobs, T. S. Matney, and A. C. Griffin,Cancer Lett. 2, 319 (1977).PubMedCrossRefGoogle Scholar
  66. 66.
    M. Demerec and J. Hanson,Cold Spring Harbor Symp. Quant. Biol. 16, 215 (1951).PubMedGoogle Scholar
  67. 67.
    A. Orgel and L. E. Orgel,J. Mol. Biol. 14, 453 (1965).PubMedGoogle Scholar
  68. 68.
    D. Brusick, F. Gletten, D. R. Jagannath, and V. Weekes,Mutation Res. 38, 386 (1976).Google Scholar
  69. 69.
    J. P. O'Neill, P. A. Brimer, R. Machanoff, G. P. Hirsch, and A. W. Hsie,Mutation Res. 45, 91 (1977).PubMedGoogle Scholar
  70. 70.
    D. Clive, K. O. Johnson, J. F. S. Spector, A. G. Bason, and M. M. M. Brown,Mutation Res. 59, 61 (1979).PubMedGoogle Scholar
  71. 71.
    E. Huberman and L. Sachs,Int. J. Cancer 13, 326 (1974).PubMedCrossRefGoogle Scholar
  72. 72.
    D. A. Amacher and S. C. Paillet,Mutation Res. 78, 279 (1980).PubMedCrossRefGoogle Scholar
  73. 73.
    T. J. Oberly, C. E. Piper, and D. S. McDonald,J. Toxicol. Environ. Health 9, 367 (1982).PubMedCrossRefGoogle Scholar
  74. 74.
    M. Miyaki, M. Akamatsu, J. Ono, and H. Koyama,Mutation Res. 68, 259 (1979).PubMedCrossRefGoogle Scholar
  75. 75.
    M. Nishimura and M. Umeda,Mutation Res. 54, 246 (1978).Google Scholar
  76. 76.
    R. F. Newbold, J. Amos, and J. R. Connell,Mutation Res. 67, 55 (1979).PubMedCrossRefGoogle Scholar
  77. 77.
    J. P. O'Neill, D. B. Couch, R. Machanoff, J. R. San Sebastian, P. A. Brimer, and A. W. Hsie,Mutation Res. 45, 103 (1977).PubMedGoogle Scholar
  78. 78.
    D. Turnbull, N. C. Popescu, J. A. Dipaolo, and B. C. Myhr,Mutation Res. 66, 267 (1979).PubMedCrossRefGoogle Scholar
  79. 79.
    R. T. Taylor, J. H. Carver, M. L. Hanna, and D. L. Wandres,Mutation Res. 67, 65 (1979).PubMedCrossRefGoogle Scholar
  80. 80.
    L. A. Zwelling, M. O. Bradley, N. A. Sharkey, T. Anderson, and K. W. Kohn,Mutation Res. 67, 271 (1979).PubMedCrossRefGoogle Scholar
  81. 81.
    M. Costa, M. K. Jones, and O. Lindberg,Amer. Chem. Soc. Symp. 140, 45 (1980).Google Scholar

Copyright information

© Humana Press Inc. 1982

Authors and Affiliations

  • J. Daniel Heck
    • 1
  • Max Costa
    • 1
  1. 1.Division of Toxicology, Department of PharmacologyUniversity of Texas Medical School at HoustonHouston

Personalised recommendations