Immunologic Research

, Volume 17, Issue 1–2, pp 3–11 | Cite as

B cell maturation and selection at the marrow-periphery interface

  • Michael P. Cancro
  • David M. Allman
  • Colleen E. Hayes
  • Vicky M. Lentz
  • Ryan G. Fields
  • Alex P. Sah
  • Mary Tomayko


More than 95% of newly formed B cells die in the short interval spanning slgM acquisition in the bone marrow and entry into the long-lived pool, suggesting that selective events dictating B cell longevity occur at this stage. These likely include both ligandinduced deletion as well as discrete events that mediate recruitment to the long-lived recirculating pool. We are probing these events through the examination of normal B cell differentiation during this critical period: the characterization of a natural mutation that blocks late maturation, an irradiation/autoreconstitution model of marrow-derived B cell differentiation, and the identification of life span regulatory genes whose expression changes within this window.

Key words

B cell longevity B cell maturation B cell differentiation 


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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Michael P. Cancro
    • 1
  • David M. Allman
    • 2
  • Colleen E. Hayes
    • 3
  • Vicky M. Lentz
    • 1
  • Ryan G. Fields
    • 1
  • Alex P. Sah
    • 1
  • Mary Tomayko
    • 1
  1. 1.Dept. of Pathol.Univ. of PennsylvaniaPhiladelphia
  2. 2.Fox Chase Cancer Research CenterPhiladelphia
  3. 3.University of WisconsinMadison

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