Biological Trace Element Research

, Volume 35, Issue 1, pp 73–75 | Cite as

Dietary iron loading does not influence biliary iron excretion in rats

  • Shiguang Yu
  • Anton C. Beynen


The effect of dietary iron loading on biliary iron excretion was investigated with male Wistar rats aged 6 wk. The rats were fed purified diets with either 174 or 1740 mg FeSO4. 7H2O/kg diet and demineralized water for 6 wk. Blood haemoglobin, hematocrit, and iron concentrations in kidney and heart were not affected and iron concentrations in liver, spleen, and tibia were significantly raised after feeding the high-iron diet. The high-iron diet did not raise biliary iron excretion, suggesting that biliary iron excretion does not play an important role in regulating iron metabolism in rat after dietary iron loading.

Index Entries

Bile iron status rat 


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  1. 1.
    E. J. Underwood,Trace Elements in Human and Animal Nutrition, Academic Press, New York, p. 13, (1977).Google Scholar
  2. 2.
    M. Cikrt, P. Poňka, E. Nečas, and J. Neuwirt,Br. J. Haematol. 45, 275 (1980).PubMedGoogle Scholar
  3. 3.
    P. Allain, G. Leblondel, and Y. Mauras,Proc. Soc. Exp. Biol. Med.,188, 471 (1988).PubMedGoogle Scholar
  4. 4.
    H. N. A. Grooten, J. Ritskes-Hoitinga, J. N. J. J. Mathot, A. G. Lemmens, and A. C. Beymen,Biol. Trace Elem. Res. 29, 147 (1991).PubMedCrossRefGoogle Scholar
  5. 5.
    Ch. Fleck, and A. Barth,Exp. Pathol. 39, 175 (1990).PubMedGoogle Scholar

Copyright information

© The Humana Press, Inc 1992

Authors and Affiliations

  • Shiguang Yu
    • 1
    • 2
    • 3
  • Anton C. Beynen
    • 1
    • 2
    • 4
  1. 1.Department of Large Animal Medicine and NutritionState UniversityUtrecht
  2. 2.Department of Human NutritionAgricultural UniversityWageningen
  3. 3.Department of Nutrition and Food HygieneXi'an Medical UniversityXi'anPeople's Republic of China
  4. 4.Department of Laboratory Animal ScienceState UniversityUtrechtThe Netherlands

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