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Applied Biochemistry and Biotechnology

, Volume 68, Issue 1–2, pp 1–20 | Cite as

Utilization of glycosyltransferases to change oligosaccharide structures

  • Zhengmao Guo
  • Peng George WangEmail author
Patents and Literature

Abstract

Carbohydrates on cell surfaces are important biomolecules in various biological recognition processes. Elucidation of the biological roles of complex oligosaccharides necessitates an efficient methodology to synthesize these compounds and their analogs. Enzymatic synthesis renders itself to be useful in the construction of an oligosaccharide structure owing to its mild reaction condition, high regio- and stereoselectivity. This review article focuses on the recent progress in oligosaccharide syntheses catalyzed by glycosyltransferases, namely sialyltransferase, galactosyltransferase, fucosyltransferase, andN-acetylglucosaminyltransferase. A survey of the latest patent and literature related to this field is also included.

Index Entries

Glycosyltransferase sialyltransferase galactosyltransferase fucosyltransferase N-acetylglucosaminyltransferase oligosaccharide 

Abbreviations

Glc

glucose

Gal

galactose

GalNAc

N-acetylgalactosamine

Fuc

fucose

GlcNAc

N-acetylglucosamine

UDP-Glc

uridine 5t’-diphosphate glucose

UDP-GlcNAc

uridine 5t’-diphosphateN-acetylglucosamine

UDP-Gal

uridine 5t’-diphosphate galactose

UDP-GalNAc

uridine 5t’-diphosphateN-acetylgalactosamine

GDP-Man

guanosine5t’-diphosphate mannose

GDP-Fuc

guanosine 5t’-diphosphate fucose

UDP-GlcUA

uridine 5t’-diphosphate glucuronic acid

CMP-Sialic acid

cytidine 5t’-monophosphate sialic acid

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Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of MiamiCoral Gables

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