The effect of aging on the mineral status of female mice
- 94 Downloads
To clarify the effect of aging on the mineral status of female mice, mineral concentrations in their tissues were determined. Five 2-mo-old, five 6-mo-old, and five 10-mo-old female B10BR mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, sodium, and potassium concentrations in the blood, liver, kidney, heart, brain, lung, and spleen of the mice were determined using a flame atomic absorption spectrophotometer. Iron concentrations in the liver, kidney, heart, brain, and spleen increased with age. Significant differences were detected between mice 2 and 6 mo of age and between mice 2 and 10 mo of age. Zinc concentrations in the heart and lung decreased significantly with age. Zinc concentrations in the heart and lung of 10-mo-old mice were significantly lower than those of 2-mo-old mice. It is noteworthy that the copper concentration in the brain of 10-mo-old mice was markedly higher compared with that of younger mice. Calcium accumulation was apparent in the kidney of mice at 10 mo.
Index EntriesAging female mice iron zinc copper calcium magnesium sodium potassium
Unable to display preview. Download preview PDF.
- 2.G. Pommer,Untersuchungen uber Osteomalacie und Rachitis Leipzig, Germany (1885).Google Scholar
- 3.H. E. Meema,J. Bone Joint Surg. 48-A, 1138–1144 (1966).Google Scholar
- 4.H. E. Meema and S. Meema,J. Am. Ger. Soc. 17, 120–141 (1969).Google Scholar
- 8.S. L. Hansard and H. M. Crowder,J. Nutr. 62, 313–324 (1957).Google Scholar
- 14.Y. Tanaka and T. Tarumi,Handbook for Statistical Analysis with Personal Computer, vol. 3 Experimental Designs, Kyoritu Syuppan Inc., Tokyo (1986).Google Scholar
- 15.S. D. Aust and B. A. Svingen,Free Radicals in Biology, vol. V W. A. Pryor, eds., Academic NY (1982).Google Scholar
- 20.S. M. Pilch and F. R. Senti,Assessment of the Iron Nutritional Status of the US Population Based on the Data Collected in the Second National Health and Nutrition Examination Survey 1976–1980, Federation of American Societies for Experimental Biology, Bethesda, MD (1984).Google Scholar
- 21.K. M. Hambidge, C. E. Casey, and N. F. Krebs,Trace Elements in Human and Animal Nutrition, vol. 2, 5th ed. Mertz, W., ed., Academic, Orlando, FL pp. 83–87 (1986).Google Scholar
- 24.A. Matsuda, M. Kimura, K. Yokoi, H. Kabata, Y. Itokawa, M. Kataoka, and M. Sato,Jpn. J. Hyg. 44, 887–893 (1989).Google Scholar
- 37.C. S. Pinkham and K. S. Kubena,Magnesium Res. 1, 147–153 (1988).Google Scholar
- 38.Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Study,J. Nutr. 107, 1340–1348 (1977).Google Scholar