Biological Trace Element Research

, Volume 42, Issue 2, pp 165–177 | Cite as

The effect of aging on the mineral status of female mice

  • Akemi Morita
  • Mieko Kimura
  • Yoshinori Itokawa


To clarify the effect of aging on the mineral status of female mice, mineral concentrations in their tissues were determined. Five 2-mo-old, five 6-mo-old, and five 10-mo-old female B10BR mice were fed a commercial diet. Iron, zinc, copper, calcium, magnesium, sodium, and potassium concentrations in the blood, liver, kidney, heart, brain, lung, and spleen of the mice were determined using a flame atomic absorption spectrophotometer. Iron concentrations in the liver, kidney, heart, brain, and spleen increased with age. Significant differences were detected between mice 2 and 6 mo of age and between mice 2 and 10 mo of age. Zinc concentrations in the heart and lung decreased significantly with age. Zinc concentrations in the heart and lung of 10-mo-old mice were significantly lower than those of 2-mo-old mice. It is noteworthy that the copper concentration in the brain of 10-mo-old mice was markedly higher compared with that of younger mice. Calcium accumulation was apparent in the kidney of mice at 10 mo.

Index Entries

Aging female mice iron zinc copper calcium magnesium sodium potassium 


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Copyright information

© Humana Press Inc. 1994

Authors and Affiliations

  • Akemi Morita
    • 1
  • Mieko Kimura
    • 1
  • Yoshinori Itokawa
    • 1
  1. 1.Department of Environmental Medicine, Graduate School of MedicineKyoto UniversityKyotoJapan

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