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Changes of CSF-Cu and -Zn in children with acute lymphoblastic leukemia

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Abstract

In 20 Dutch children with acute lymphoblastic leukemia (ALL), Cu and Zn levels in cerebrospinal fluid (CSF) were studied during standard treatment (Protocol ALL-BFM-86/SNWLK-ALL-VII). CSF-Cu in 10 controls was 0.04±0.02 μmol/L, lower compared to values in adults. At the moment of diagnosis, CSF-Cu values were higher, 0.06±0.03 μmol/L, and during maintenance therapy lower, 0.01±0.01 μmol/L. Children with central nervous system (CNS) involvement ALL as judged by CAT Scan and EEG—in addition to cytology—showed lower CSF-Cu values compared to children without.

CSF-Zn values were also measured. CSF-Zn was 0.05 μmol/L and did not vary. Cu/Zn molar ratios were increased at the onset of treatment, and decreased during maintenance therapy.

The changes in CSF-Cu may follow the natural course of the disease or may relate to the success of treatment, reflecting a decrease of leukemia activity. Another explanation concerns a risk to CNS damage by low CSF-Cu causing neuron dysfunction. Conditions necessary for the interpretation of these results into a clinical strategy for followup study are outlined.

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Authors and Affiliations

  1. Department of Pediatrics, State University at Leiden, Delft, the Netherlands

    Jacobus P. Van Wouwe & Margreet H. Van Weel-Sipman

  2. Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, Delft, the Netherlands

    Jacobus P. Van Wouwe

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  1. Jacobus P. Van Wouwe
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  2. Margreet H. Van Weel-Sipman
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Van Wouwe, J.P., Van Weel-Sipman, M.H. Changes of CSF-Cu and -Zn in children with acute lymphoblastic leukemia. Biol Trace Elem Res 38, 243–250 (1993). https://doi.org/10.1007/BF02785309

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  • DOI: https://doi.org/10.1007/BF02785309

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