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Inflammatory pseudotumor of the pancreas

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Summary

We describe a rare example of inflammatory pseudotumor of the pancreas in a 42-yr-old woman, which developed following chemotherapy for lymphoma of the uterine cervix. The patient had developed fatigue, weight loss abdominal pain, and anemia; abdominal CT scan showed a large mass in the pancreas. Examination of the resected specimen revealed a fleshy, well-circumscribed, 7-cm mass., Histologically, there was a hypocellular to moderately hypercellular, bland spindle-cell proliferation admixed with a prominent infiltrate of lymphocytes, histiocytes, and plasma cells. The spindle cells were vimentin positive but negative for muscle markers; electron microscopy revealed only fibroblastic cells. DNA analysis revealed a diploid population with low S-phase fraction. The patient was well at 6-mo follow-up. It is important for the pathologist to be aware of the existence of this entity in unusual locations such as the pancreas so as to avoid a mistaken diagnosis of malignancy.

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References

  1. Pettinato G, Manivel C, DeRosa N, Dehner LP. Inflammatory myofibroblastic tumor (plasma cell granuloma): clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations.Am J Clin Pathol 1990; 94: 538–546.

    PubMed  CAS  Google Scholar 

  2. Anthony PP. Inflammatory pseudotumor (plasma cell granuloma) of lung, liver, and other organs.Histopathology 1993; 23: 501–503.

    Article  PubMed  CAS  Google Scholar 

  3. Jones EC, Clement PB, Young RH. Inflammatory pseudotumor of the urinary bladder.Am J Surg Pathol 1993; 17: 264–274.

    Article  PubMed  CAS  Google Scholar 

  4. Palazzo JP, Chang CD. Inflammatory pseudotumor of the pancreas.Histopathology 1993; 23: 475–477.

    Article  PubMed  CAS  Google Scholar 

  5. Shek TWH, Ng IOL, Chan KW. Inflammatory pseudotumor of the liver: report of four cases and review of the literature.Am J Surg Pathol 1993; 17: 231–238.

    Article  PubMed  CAS  Google Scholar 

  6. Hurt MA, Santa Cruz DJ. Cutaneous inflammatory pseudotumor: lesions resembling “inflammatory pseudotumors” or “plasma cell granulomas” of extracutaneous sites.Am J Surg Pathol 1990; 14: 764–773.

    PubMed  CAS  Google Scholar 

  7. Scott L, Blair G, Taylor G, Dimmick J, Fraser G. Inflammatory pseudotumors in children.J Pediatr Surg 1988; 23: 755–758.

    Article  PubMed  CAS  Google Scholar 

  8. Harlow S, Roth SI, Bauer K, Marshall RB. Flow cytometric analysis of normal and pathologic parathyroid glands.Mod Pathol 1991; 4: 310–315.

    PubMed  CAS  Google Scholar 

  9. Hedley DW, Friedlander ML, Taylor ZW, et al. Method for analysis of cellular DNA content of paraffin-embedded material using flow cytometry.J Histochem Cytochem 1983; 31: 1333–1335.

    PubMed  CAS  Google Scholar 

  10. Abrebanel P, Sarfaty S, Gal R, Chaimoff C, Kessler E. Plasma cell granuloma of the pancreas.Arch Pathol Lab Med 1984; 108: 531532.

    PubMed  CAS  Google Scholar 

  11. Dudiak KM. Inflammatory pseudotumor of the pancreas.AJR 1993; 160: 13241325.

    PubMed  CAS  Google Scholar 

  12. Treissman SP, Gillis DA, Lee CLY, Giacomantonio M, Resch L. Omental-mesenteric inflammatory pseudotumor: cytogenetic demonstration of genetic changes and monoclonality in one tumor.Cancer 1994; 73: 1433–1437.

    Article  PubMed  CAS  Google Scholar 

  13. Albores-Saavedra J, Manivel JC, Essenfeld H, et al. Pseudosarcomatous myofibroblastic proliferations in the urinary bladder of children.Cancer 1990; 66: 1234–1241.

    Article  PubMed  CAS  Google Scholar 

  14. Myint MA, Medeiros LJ, Sulaiman RA, Aswad BI, Glantz L. Inflammatory pseudotumor of the ileum. A report of a multifocal, transmural lesion with regional lymph node involvement.Arch Pathol Lab Med 1994; 118: 1138–1142.

    PubMed  CAS  Google Scholar 

  15. Brardi RS, Lee SS, Chen HP, Stines GJ. Inflammatory pseudotumors of the lung.Surg Gynecol Obstet 1983; 156: 89–96.

    Google Scholar 

  16. Gal AA, Koss MN, McCarthy WF, Hochholzer L. Prognostic factors in pulmonary fibrohistiocytic lesions.Cancer 1994; 73: 1817–1824.

    Article  PubMed  CAS  Google Scholar 

  17. Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum.Am J Surg Pathol 1991; 15: 1146–1156.

    Article  PubMed  CAS  Google Scholar 

  18. Uzoaru I, Chou P, Reyes-Mugica M, Shen-Schwarz S, Gonzalez-Crussi F. Inflammatory myofibroblastic tumor of the pancreas.Surg Pathol 1993; 5: 181–188.

    Google Scholar 

  19. Reimenschneider RA, Wilson JF, Vernier RL. Glucocorticoid-induced pancreatitis in children.Pediatrics 1968; 41: 428–437.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Northwestern University Medical School, Passavant Pavilion Rm. 316, 303 E. Superior, 60611, Chicago, IL

    Steven H. Kroft & M. Sambasiva Rao

  2. Department of Surgery, Northwestern University Medical School, Passavant Pavilion Rm. 316, 303 E. Superior, 60611, Chicago, IL

    Steven J. Stryker & Jane N. Winter

  3. Department of Medicine, Northwestern University Medical School, Passavant Pavilion Rm. 316, 303 E. Superior, 60611, Chicago, IL

    Gulchi Ergun

Authors
  1. Steven H. Kroft
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  2. Steven J. Stryker
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  3. Jane N. Winter
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  4. Gulchi Ergun
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  5. M. Sambasiva Rao
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Kroft, S.H., Stryker, S.J., Winter, J.N. et al. Inflammatory pseudotumor of the pancreas. Int J Pancreatol 18, 277–283 (1995). https://doi.org/10.1007/BF02784953

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  • DOI: https://doi.org/10.1007/BF02784953

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