Journal of Pharmaceutical Innovation

, Volume 1, Issue 1, pp 44–53 | Cite as

Design space for a solventless photocurable pharmaceutical coating

  • Sagarika Bose
  • Brendan Kelly
  • Robin H. Bogner
Research Article


Solventless coating technologies can overcome many of the disadvantages associated with using solvents in pharmaceutical coating. A solventless photocurable film-coating system was investigated in which liquid photocurable prepolymer and powdered pore-forming agents were applied onto non-pareil beads in a mini-coating pan. The beads were exposed to light after each coating layer. Using lactose as a filler, an optimum range of filler to photocurable polymer ratio was 1.8 to 3.0 to achieve good process efficiency and uniformity. The ratio was sensitive to particle size and filler type. The initiator concentration and light intensity also were evaluated. The time required to coat a batch was dramatically reduced compared with conventional film coating.


Lactose DMAEMA Coating Efficiency Free Film Pharmaceutical Innovation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© International Society for Pharmaceutical Engineering 2006

Authors and Affiliations

  • Sagarika Bose
    • 1
    • 2
  • Brendan Kelly
    • 1
    • 3
  • Robin H. Bogner
    • 1
    • 4
  1. 1.Department of Pharmaceutical SciencesUniversity of ConnecticutStorrsUSA
  2. 2.Wyeth PharmaceuticalsPearl RiverUSA
  3. 3.Merck & Co., Inc.West pointUSA
  4. 4.Institute of Materials ScienceUniversity of ConnecticutStorrsUSA

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