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Biological Trace Element Research

, Volume 32, Issue 1–3, pp 421–426 | Cite as

Interleukin 2 production in iron-deficient children

  • Pilar Galan
  • Helene Thibault
  • Paul Preziosi
  • Serge Hercberg
Part 2: Trace elements in endocrinology Section 5: Reproduction, Growth, and Immunity

Abstract

The relationship between iron status and capacity for IL-2 production by lymphocytes was assessed in 81 children from 6 mo to 3 yr of age selected at random from a population with low socioeconomic status, undergoing free systematic examination in four children's health centers in the Paris area. Iron deficiency was defined by the existence of at least two abnormal values among the three indicators of iron status: serum ferritin level ≤12 μg/L, transferrin saturation <12%, and erythrocyte protoporphyrin concentration >3 μg/g hemoglobin. According to this definition, 53 children were classified as iron deficient and 28 as iron sufficient. No differences were observed between the iron-deficient and iron-sufficient groups in terms of the IL-2 concentration without stimulation by PHA. IL-2 production by lymphocytes stimulated with PHA, as well as the stimulation index (ratio of IL-2 concentration following stimulation by PHA to that of IL-2 concentration without stimulation by PHA) were significantly lower in iron-deficient children. The reduction in IL-2 production by activated lymphocytes observed in our study of iron-deficient children may be responsible for impairments in immunity found by other authors, particularly in cell-mediated immunity.

Index Entries

Iron deficiency interleukin production iron status and immunity T-lymphocyte subsets 

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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Pilar Galan
    • 1
  • Helene Thibault
    • 1
  • Paul Preziosi
    • 1
  • Serge Hercberg
    • 1
  1. 1.Institut Scientifique et Technique de la Nutrition et de l'AlimentationCNAMParisFrance

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