Biological Trace Element Research

, Volume 32, Issue 1–3, pp 355–360 | Cite as

Effects of acute prednisolone administration on plasma and liver copper in rats with adjuvant arthritis

  • Jeanine Fontaine
  • Jean Neve
  • Anne Peretz
  • Jean-Pierre Famaey
Part 2: Trace elements in endocrinology Section 4: Kidneys, Adrenals, and Corticosteroid Hormones


Several studies in animals and humans have shown that copper metabolism could be affected by inflammation or by corticosteroids. The relative importance of these two factors, often imbedded in clinical practice, was assessed by investigating the effects of acute prednisolone administration (30 mg/kg, ip) on healthy and adjuvant arthritis rats. Plasma copper levels were significantly higher in arthritic rats compared to healthy animals, whereas there was a slight, but nonsignificant increase in liver copper. Acute prednisolone administration in healthy rats resulted in a significant increase in plasma copper (10–15%) as early as 4 h after corticosteroid administration, which was maintained for 12 h. In arthritic rats, the response was much higher (25–40%), but somewhat delayed and shorter. Liver copper was not clearly modified by prednisolone treatment in both groups. This time-controlled study showed that acute prednisolone administration increased plasma copper in both healthy and arthritic rats, but in different ways, indicating that inflammation and corticosteroids may act synergistically.

Index Entries

Adjuvant arthritis inflammation copper corticosteroid liver plasma rats 


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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Jeanine Fontaine
    • 1
  • Jean Neve
    • 2
  • Anne Peretz
    • 3
  • Jean-Pierre Famaey
    • 3
  1. 1.Department of Pharmacology, Institute of PharmacyUniversity of BrusselsBrusselsBelgium
  2. 2.Department of Pharmaceutical Organic Chemistry, Institute of PharmacyUniversity of BrusselsBrusselsBelgium
  3. 3.Department of Rheumatology and Physical MedicineSaint-Pierre HospitalBrusselsBelgium

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