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Biological Trace Element Research

, Volume 32, Issue 1–3, pp 331–335 | Cite as

Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes

  • Marie Jeanne Gomot
  • Patrice Faure
  • Anne-Marie Roussel
  • Charles Coudray
  • Mireille Osman
  • Alain Favier
Part 2: Trace elements in endocrinology Section 3: Diabetes and Glucose Tolerance

Abstract

Considerable data have been reported on the relationship between insulin resistance and zinc deficiency. In this study, insulin receptor binding was measured in isolated rat adipocytes. Two assays were carried out at 37°C (binding and internalization) and 16°C (binding) using125I insulin 0.05–20 nM. A decreased insulin receptor binding was observed in zinc-deficient rat adipocytes, but we could not make any distinction between the specific zinc depletion effects and the effects of the caloric restriction induced by zinc deficiency.

Index Entries

Insulin resistance zinc deficiency rat adipocytes insulin binding 

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Copyright information

© The Huaman Press, Inc 1992

Authors and Affiliations

  • Marie Jeanne Gomot
    • 1
  • Patrice Faure
    • 1
  • Anne-Marie Roussel
    • 2
  • Charles Coudray
    • 1
  • Mireille Osman
    • 2
  • Alain Favier
    • 1
  1. 1.Laboratoire de Biochimie CHôpital A. MichallonGrenoble CédexFrance
  2. 2.Laboratoire de Biochimie CUFR de PharmacieLa TroncheFrance

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