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Chromium metabolism

A literature review

  • Part 1: Chromium
  • Section 1: Biological Status and Nutritional Aspects
  • Published:
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Abstract

The trivalent state of chromium (Cr3+) is that encountered in biological milieus and is responsible for its nutritional activity. The principal route by which trivalent chromium enters the body is the digestive system. Chromium in foods is present both in the inorganic form and as organic complexes. Intestinal absorption of chromium is low (0.5–2%), and the mechanism has not yet been fully elucidated. Absorbed chromium circulates as free Cr3+, as Cr3+ bound to transferrin or other plasma proteins, or as complexes, such as glucose tolerance factor (GTF)-Cr. Circulating trivalent chromium can be taken up by tissues, and its distribution in the body depends on the species, age, and chemical form. It is excreted primarily in the urine by glomerular filtration or bound to a low-mol-wt organic transporter. Chromium metabolism is still imperfectly understood. The use of51Cr has nevertheless furnished valuable data concerning its transport and excretion.

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References

  1. S. Wallach,J. Am. Coll. Nutr. 4, 107–120 (1985).

    PubMed  CAS  Google Scholar 

  2. W. Mertz,Nutr. Rev. 81, 129–135 (1975).

    Google Scholar 

  3. M. Anderson, D. Riley, and J. Rotruck,Fed. Proc. 39, 787 (1980).

    Google Scholar 

  4. R. A. Anderson,Trace Elements in Human and Animal Nutrition, vol. 1, W. Mertz, ed., Academic, New York, 1987, pp. 225–244.

    Google Scholar 

  5. W. Mertz,Physiol. Rev. 49, 163–239 (1969).

    PubMed  CAS  Google Scholar 

  6. B. E. Guthrie,Biological and Environmental Aspects of Chromium, S. Langard, ed., Elsevier Biomedical, Amsterdam, 1982, pp. 117–148.

    Google Scholar 

  7. R. A. Anderson and N. A. Bryden,J. Agric. Food Chem. 31, 308–311 (1983).

    Article  PubMed  CAS  Google Scholar 

  8. N. S. C. Chen, A. Tsai, and I. A. Dyer,J. Nutr. 103, 1182–1186 (1973).

    PubMed  CAS  Google Scholar 

  9. R. J. Doisy, D. P. H. Streeten, J. M. Freiberg, and A. J. Schneider,Trace Elements in Human Health and Disease, vol. II, A. S. Prasad and D. Oberleas, eds., Academic, New York, 1976, pp. 79–104.

    Google Scholar 

  10. W. Mertz, E. E. Roginski, and R. C. Reba,Am. J. Physiol. 209, 489–494 (1965).

    PubMed  CAS  Google Scholar 

  11. R. M. Donaldson and R. F. Barreras,J. Lab. Clin. Med. 68, 484–493 (1966).

    PubMed  CAS  Google Scholar 

  12. W. Mertz and E. E. Roginski,Newer Trace Elements in Nutrition, W. Mertz and W. E. Cornatzer, eds., Dekker, New York, 1971, pp. 123–153.

    Google Scholar 

  13. H. J. Dowling, E. G. Offenbacher, and F. X. Pi-Sunyer,Fed. Proc. 45, 484 (1986).

    Google Scholar 

  14. H. J. Dowling, E. G. Offenbacher, and F. X. Pi-Sunyer,J. Nutr. 119, 1138–1145 (1989).

    PubMed  CAS  Google Scholar 

  15. M. Urberg, M. Parent, D. Mill, and M. Zemel,Diabetes 35, 37a (1986).

    Google Scholar 

  16. M. N. Wang, Y. C. Li, K. Odalut, and B. J. Stoecker,Fed. Proc. 44, 751 (1985).

    Google Scholar 

  17. C. D. Seaborn and B. J. Stoecker,J. Nutr. 119, 1444–1451 (1989).

    PubMed  CAS  Google Scholar 

  18. L. Solvell,Acta Med. Scand. 168 (suppl. 358), 71–104 (1960).

    CAS  Google Scholar 

  19. C. J. Hahn and G. W. Evans,Am. J. Physiol. 228, 1020–1023 (1975).

    PubMed  CAS  Google Scholar 

  20. C. H. Hill,Trace Elements in Human Disease, A. S. Prasad, ed., Academic, New York, 1975, pp. 281–300.

    Google Scholar 

  21. L. L. Hopkins, Jr. and K. Schwarz,Biochim. Biophys. Acta 90, 484–491 (1964).

    PubMed  CAS  Google Scholar 

  22. R. A. Anderson and A. S. Kozlovsky,Am. J. Clin. Nutr. 41, 1177–1183 (1985).

    PubMed  CAS  Google Scholar 

  23. Y. Sayato, K. Nakamuro, S. Matsui and M. Ando,J. Pharm. Dyn. 3, 17–23 (1980).

    CAS  Google Scholar 

  24. A. Yamamoto, O. Wada, and T. Ono,J. Inorg. Biochem. 22, 91–102 (1984).

    Article  PubMed  CAS  Google Scholar 

  25. H. A. Schroeder, J. J. Balassa, and I. H. Tipton,J. Chronic. Dis. 15, 941–964. (1962).

    Article  PubMed  CAS  Google Scholar 

  26. H. A. Schroeder, A. P. Nason, and I. H. Tipton,J. Chronic. Dis. 23, 123–142 (1970).

    Article  PubMed  CAS  Google Scholar 

  27. J. M. Morgan,Metab. Clin. Exp. 21, 313–316 (1972).

    PubMed  CAS  Google Scholar 

  28. D. J. Eatough, L. O. Hansen, S. E. Starr, M. S. Astin, S. B. Larsen, R. M. Izatt, and J. J. Christensen,Trace Element Metabolism in Man and Animals, vol. III, M. Kirchgessner, ed., Institut fur Ernahrungspysislogie, Freising-Weihenstephan, 1978, pp. 259–263.

    Google Scholar 

  29. W. J. Visek, I. B. Whitney, U. S. G. Kuhn, III, and C. L. Comar,Proc. Soc. Exp. Biol. Med. 84, 610–615 (1953).

    PubMed  CAS  Google Scholar 

  30. J. Edel, E. Sabbioni, R. Pietra, B. Wallaeys, and L. Manzo,Trace Elements in Man and Animals, vol. 5, C. F. Mills, I. Bremner, and J. K. Chesters, eds., Commonwealth Agricultural Bureaux, Aberdeen, 1985, pp. 702–707.

    Google Scholar 

  31. L. Kraintz and R. V. Talmage,Proc. Soc. Exp. Biol. Med. 81, 490–492 (1952).

    PubMed  CAS  Google Scholar 

  32. P. O. Berggren, and P. R. Flatt,Nutr. Rep. Int. 31, 213–218 (1985).

    CAS  Google Scholar 

  33. L. L. Hopkins, Jr.,Am. J. Physiol. 209, 731–735 (1965).

    PubMed  Google Scholar 

  34. S. Wallach and R. L. Verch,J. Am. Coll. Nutr. 5, 291–298 (1986).

    PubMed  CAS  Google Scholar 

  35. S. Wallach and R. L. Verch,Trace Elements in Medicine 6, 9–11 (1989).

    CAS  Google Scholar 

  36. R. K. Mathur and R. J. Doisy,Proc. Soc. Exp. Biol. Med. 139, 836–838 (1972).

    PubMed  CAS  Google Scholar 

  37. I. Raz, J. H. Adler, and E. Havivi,Diabetologia 31, 329–333 (1988).

    Article  PubMed  CAS  Google Scholar 

  38. R. J. Doisy, D. P. H. Streeten, M. L. Souma, M. E. Kalafer, S. L. Rekant, and T. G. Dalakos,Newer Trace Element in Nutrition, W. Mertz and W. E. Cornatzer, eds., Dekker, New York, 1971, pp. 155–168.

    Google Scholar 

  39. M. Florkin and E. H. Stotz,Comprehensive Biochemistry, vol. 21, Elsevier, 1971, pp. 230–233.

  40. R. A. Anderson, M. M. Polansky, N. A. Bryden, E. E. Roginski, K. Y. Patterson, C. Veillon, and W. H. Glinsmann,Am. J. Clin. Nutr. 36, 1184–1193 (1982).

    PubMed  CAS  Google Scholar 

  41. R. A. Anderson, M. M. Polansky, N. A. Bryden, K. Y. Patterson, C. Veillon, and W. H. Glinsmann,J. Nutr. 113, 276–281 (1983).

    PubMed  CAS  Google Scholar 

  42. D. L. Donaldson and O. M. Rennert,Ann. Clin. Lab. Science 11, 377–385 (1981).

    CAS  Google Scholar 

  43. D. L. Donaldson, C. C. Smith, and A. A. Yunice,Am. J. Physiol. 246, F870-F878 (1984).

    PubMed  CAS  Google Scholar 

  44. G. Y. Wu and O. Wada,Jpn. J. Ind. Health 23, 505–512 (1981).

    CAS  Google Scholar 

  45. S. Wallach and R. L. Verch,J. Am. Coll. Nutr. 2, 163–172 (1983).

    PubMed  CAS  Google Scholar 

  46. S. Wallach and R. L. Verch,J. Am. Coll. Nutr. 5, 299–304 (1986).

    PubMed  CAS  Google Scholar 

  47. C. Onkelinx,Am. J. Physiol. 232, E478-E484 (1977).

    PubMed  CAS  Google Scholar 

  48. R. Jain, R. L. Verch, S. Wallach, and R. A. Peabody,Am. J. Clin. Nutr. 34, 2199–2204 (1981).

    PubMed  CAS  Google Scholar 

  49. T. H. Lim, T. Sargent III, and N. Kusubov,Am. J. Physiol. 244, R445-R454 (1983).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Biochimie C, Hôpital A. Michallon, BP 217X, 38043, Grenoble Cedex, France

    Véronique Ducros

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Ducros, V. Chromium metabolism. Biol Trace Elem Res 32, 65–77 (1992). https://doi.org/10.1007/BF02784589

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  • DOI: https://doi.org/10.1007/BF02784589

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