Biological Trace Element Research

, Volume 60, Issue 3, pp 205–213 | Cite as

Calcium, magnesium, and zinc status in experimental hypothyroidism

  • Gonul ŞimŞek
  • Gulnur Andican
  • Yunus Karako©
  • Gunner Yiğit
  • Husrev Hatemi
  • Gulden Candan
Original Articles


In this study, experimental hypothyroidism was established and used to investigate possible alterations in the calcium, magnesium, and zinc homeostasis by assessing their concentration in plasma and erythrocytes. Hypothyroidism was induced by administration of methimazole an iodine blocker at a dose of 75 mg/100 g food for 3 wk.

In the methimazole-induced hypothyroid state, the experimental animals showed a significant decrease in plasma zinc concentration, whereas a significant increase in plasma magnesium concentration occurred. No change was observed in plasma calcium concentration. The erythrocyte zinc and calcium concentrations were found to be increased, whereas magnesium concentration decreased. Erythrocyte magnesium concentration showed a significant positive correlation with T4 values.

The study provides evidence for marked alterations in homeostatis of zinc, magnesium, and calcium.

Index Entries

Hypothyroidism calcium magnesium zinc 


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Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Gonul ŞimŞek
    • 1
  • Gulnur Andican
    • 2
  • Yunus Karako©
    • 3
  • Gunner Yiğit
    • 1
  • Husrev Hatemi
    • 4
  • Gulden Candan
    • 2
  1. 1.Department of Physiology, Faculty of MedicineUniversity of IstanbulCerrahpasa, IstanbulTurkey
  2. 2.Department of Biochemistry, Faculty of MedicineUniversity of IstanbulCerrahpasa, IstanbulTurkey
  3. 3.Department of Biophysics, Faculty of MedicineUniversity of IstanbulCerrahpasa, IstanbulTurkey
  4. 4.Department of Endocrinology, Faculty of MedicineUniversity of IstanbulCerrahpasa, IstanbulTurkey

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