Biological Trace Element Research

, Volume 54, Issue 3, pp 213–230 | Cite as

Zinc and iron as bioindicators of precancerous nature of oral submucuos fibrosis

  • R. R. Paul
  • J. Chatterjee
  • A. K. Das
  • S. K. Dutta
  • D. Roy
Original Articles


Oral Submucous Fibrosis (OSF) is a precancerous condition of oral cavity and oropharynx. Its etiopathogenesis is still obscure. Epithelial dysplasia is considered an important indicator of it. In the present study, the authors try to ascertain bioinorganic parameters as alternate indicators of malignant potential of OSF along with other clinicopathological attributes. They also try to identify causative factors. Thirty-six OSF patients, showing different degrees of epithelial dysplasia, and 12 normal individuals are studied with special reference to trace metal contents (Zn and Fe) in oral tissues. Statistical analyses of data indicate that trace metal contents can be regarded as an alternate indicator of the precancerous nature of OSF. Some clinicopathological attributes that are easier and cheaper to measure may also indicate OSF.

Index Entries

OSF dysplasia trismus trace metals association chi-square ANOVA discriminant function 


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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • R. R. Paul
    • 1
  • J. Chatterjee
    • 2
  • A. K. Das
    • 2
  • S. K. Dutta
    • 3
  • D. Roy
    • 4
  1. 1.Department of Oral Pathology and MicrobiologyR. Ahmed Dental College and HospitalCalcuttaIndia
  2. 2.Department of ChemistryUniversity of BurdwanIndia
  3. 3.Department of Pathology University College of MedicineUniversity of CalcuttaIndia
  4. 4.Technical Group for Statistical Consultancy, Computer and Statistical Service CentreIndian Statistical InstituteCalcuttaIndia

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