Biological Trace Element Research

, Volume 71, Issue 1, pp 611–616 | Cite as

Elemental analysis of blood of nigerian hypertensive subjects

  • O. A. Akanle
  • A. Akintanmide
  • M. A. Durosinmi
  • A. F. Oluwole
  • N. M. Spyrou
Section 6: Determinations of Trace Elements in Clinical and Health-Related Studies


Proton-induced X-ray emission (PIXE) has been used to obtain the concentrations of 11 elements (P, S, Cl, K, Ca, Fe, Cu, Zn, Br, Rb, and Cd) in whole-blood samples of 16 hypertensive subjects (mean age: 52.5 ± 0.5 yr) and 18 age-matched controls (mean age: 51.5 ± 0.5 yr) in a Nigerian population. The results of the study indicate that the hypertensive subjects have significantly higher mean concentration of Cl, Cd, Cu, and Zn when compared with the controls, and the mean concentration of P, K, and Ca was found to be significantly lower in the hypertensive group in comparison to the controls. Furthermore, the Zn : Cd ratio was found to be significantly higher in the controls than in the hypertensives, and the Cu : Zn ratio was significantly higher in the hypertensives.

Index Entries

Trace elements hypertension blood pressure PIXE 


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Copyright information

© Humana Press Inc. 1999

Authors and Affiliations

  • O. A. Akanle
    • 1
  • A. Akintanmide
    • 2
  • M. A. Durosinmi
    • 3
  • A. F. Oluwole
    • 4
  • N. M. Spyrou
    • 1
  1. 1.Department of PhysicsUniversity of SurreyGuildfordUK
  2. 2.Departments of MedicineObafemi Awolowo UniversityIle-IfeNigeria
  3. 3.Departments of HaematologyObafemi Awolowo UniversityIle-IfeNigeria
  4. 4.Departments of PhysicsObafemi Awolowo UniversityIle-IfeNigeria

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