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Biological Trace Element Research

, Volume 33, Issue 1–3, pp 71–77 | Cite as

Selenium status of patients with Balkan endemic nephropathy

  • Momčilo Mihailović
  • Paul Lindberg
  • Ivan Jovanović
  • Duŝan Antić
Article

Abstract

The selenium (Se) contents in common cereals in endemic and nonendemic areas in Serbia are very low. Plasma Se levels of both patients and healthy subjects, were also low, reflecting low Se intakes. Patients with Balkan endemic nephropathy (BEN) had significantly lower (p<0.05) plasma Se levels than healthy individuals, both from regions close to endemic areas, and from Belgrade. Mean plasma Se of BEN patients was slightly but insignificantly higher in samples taken immediately after dialysis than in those taken before, suggesting that very little of the Se present in plasma is dialyzable. Plasma SeGSH-Px activities before and after hemodialysis in both BEN and Nonendemic chronic renal failure (NCRF) patients were not significantly different, but BEN patients had lower enzyme activities than those with NCRF and healthy controls. In BEN patients, a significant correlation between plasma Se and SeGSH-Px activity was found.

Index Entries

Selenium glutathione peroxidase blood plasma cereals Balkan endemic nephropathy 

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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Momčilo Mihailović
    • 1
  • Paul Lindberg
    • 2
  • Ivan Jovanović
    • 1
  • Duŝan Antić
    • 3
  1. 1.Department of Physiology and BiochemistryFaculty of Veterinary MedicineBelgradeYugoslavia
  2. 2.Department of BiochemistryCollege of Veterinary MedicineHelsinkiFinland
  3. 3.Center for HaemodialysisPožarevacYugoslavia

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