Biological Trace Element Research

, Volume 37, Issue 2–3, pp 137–149 | Cite as

Effect of coenzyme Q10 supplementation on cardiac hypertrophy of male rats consuming a high-fructose, low-copper diet

  • Charles G. Lewis
  • Meira Fields
  • Willard A. Burns
  • Mark D. Lure


Administration of coenzyme Q10 to humans and animals has a beneficial effect on a number of cardiac diseases. The purpose of the present study was to determine if coenzyme Q10 treatment could ameliorate cardiac abnormalities associated with the carbohydrate × copper interaction in rats. Weanling male rats were provided with a copper-deficient diet (0.6 μg Cu/g) containing either 62.7% starch (S−Cu) or fructose (F−Cu) for 5 wk. Half of the rats provided with the F−Cu diet were given daily oral supplements of 300 mg coenzyme Q10/kg body weight (F−Cu+Q). Heart hypertrophy, liver enlargement, or pancreatic atrophy were not affected by, nor was body growth or anemia improved by, supplementation with coenzyme Q10 when compared to rats fed only the F−Cu diet. Hearts from rats fed the F−Cu diet had severe inflammation, degeneration, fibrosis, and giant mitochondria with abnormal cristae. Hearts from F−Cu+Q rats had similar mitochondrial changes as the F−Cu rat hearts but without any apparent degenerative changes. None of the F−Cu+Q rats, but 30% of the F−Cu rats, died during the study as a result of heart rupture. These observations show that whereas coenzyme Q10 treatment did not prevent the cardiac hypertrophy of the carbohydrate × copper interaction, it did play a role in maintaining the integrity of the heart.

Index Entries

Copper deficiency heart ultrastructure carbohydrate × copper interaction cardiac pathology antioxidant 


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Copyright information

© The Humana Press, Inc 1993

Authors and Affiliations

  • Charles G. Lewis
    • 1
  • Meira Fields
    • 2
  • Willard A. Burns
    • 3
  • Mark D. Lure
    • 1
  1. 1.ARS, BHNRC, Carbohydrate Nutrition LaboratoryUSDABeltsville
  2. 2.Division of EndocrinologyGeorgetown University Medical CenterWashington, D.C.
  3. 3.Laboratory ServiceVeterans Administration HospitalEast Orange

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