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Biological Trace Element Research

, Volume 37, Issue 2–3, pp 137–149 | Cite as

Effect of coenzyme Q10 supplementation on cardiac hypertrophy of male rats consuming a high-fructose, low-copper diet

  • Charles G. Lewis
  • Meira Fields
  • Willard A. Burns
  • Mark D. Lure
Article

Abstract

Administration of coenzyme Q10 to humans and animals has a beneficial effect on a number of cardiac diseases. The purpose of the present study was to determine if coenzyme Q10 treatment could ameliorate cardiac abnormalities associated with the carbohydrate × copper interaction in rats. Weanling male rats were provided with a copper-deficient diet (0.6 μg Cu/g) containing either 62.7% starch (S−Cu) or fructose (F−Cu) for 5 wk. Half of the rats provided with the F−Cu diet were given daily oral supplements of 300 mg coenzyme Q10/kg body weight (F−Cu+Q). Heart hypertrophy, liver enlargement, or pancreatic atrophy were not affected by, nor was body growth or anemia improved by, supplementation with coenzyme Q10 when compared to rats fed only the F−Cu diet. Hearts from rats fed the F−Cu diet had severe inflammation, degeneration, fibrosis, and giant mitochondria with abnormal cristae. Hearts from F−Cu+Q rats had similar mitochondrial changes as the F−Cu rat hearts but without any apparent degenerative changes. None of the F−Cu+Q rats, but 30% of the F−Cu rats, died during the study as a result of heart rupture. These observations show that whereas coenzyme Q10 treatment did not prevent the cardiac hypertrophy of the carbohydrate × copper interaction, it did play a role in maintaining the integrity of the heart.

Index Entries

Copper deficiency heart ultrastructure carbohydrate × copper interaction cardiac pathology antioxidant 

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References

  1. 1.
    C. H. Gallagher,Aust. Vet. J. 33, 311–317 (1957).Google Scholar
  2. 2.
    D. I. Paynter, R. J. Moir, and E. J. Underwood,J. Nutr. 109, 1570–1576 (1979).PubMedGoogle Scholar
  3. 3.
    N. Rusinko and J. R. Prohaska,J. Nutr. 115, 936–943 (1985).PubMedGoogle Scholar
  4. 4.
    R. S. Redman, M. Fields, S. Reiser, and J. C. Smith, Jr.,Atherosclerosis 74, 203–214 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    W. A. Burns, M. Fields, J. C. Smith, Jr., and S. Reiser,J. Trace Elem. Exp. Med. 3, 67–77 (1990).Google Scholar
  6. 6.
    D. M. Medeiros, D. Bagby, G. Ovecka, and R. McCormick,J. Nutr. 121, 815–824 (1991).PubMedGoogle Scholar
  7. 7.
    W. T. Johnson and J. T. Saari,Nutr. Res. 9, 1355–1362 (1989).CrossRefGoogle Scholar
  8. 8.
    P. H. Langsjoen, K. Folkers, K. Lysons, K. Muratsu, T. Lyson and P. Langsjoen,Klin. Wochenschr. 66, 583–590 (1988).PubMedCrossRefGoogle Scholar
  9. 9.
    F. Okamoto, B. S. Allen, G. D. Buckberg, J. Leaf, and H. J. Bugyi,Thorac. Cardiovasc. Surg. 92, 573–582. (1986).Google Scholar
  10. 10.
    T. Yuzuriha, M. Takada, and K. Katazama,Biochim. Biophys. Acta 759, 286–291 (1983).PubMedGoogle Scholar
  11. 11.
    T. Ozawa,Coenzyme Q: Biochemistry, Bioenergetics and Clinical Applications of Ubiquione, G. Lenaz, ed. John Wiley and Sons, Chichester, 1980, pp. 441–456.Google Scholar
  12. 12.
    R. E. Beyer, K. Nordenbrand, and L. Ernster,Biomedical and Clinical Aspects of Coenzyme Q, K. Folkers and Y. Yamamura, eds. Elsevier Science Publ. Amsterdam, Holland, 1977, pp. 17–24.Google Scholar
  13. 13.
    P. H. Langsjoen, K. Folkers, K. Lyson, K. Muratsu, T. Lyson, and P. Langsjoen,Int. J. Tiss. Reac. XII, 163–168 (1990).Google Scholar
  14. 14.
    American Institute of Nutrition: Report on the AIN ad hoc committee on standards for nutritional studies,J. Nutr. 107, 1340–1348 (1977).Google Scholar
  15. 15.
    American Institute of Nutrition: Second report of the AIN ad hoc committee on standards for nutritional studies.J. Nutr. 110, 1726 (1980).Google Scholar
  16. 16.
    C. G. Lewis, M. Fields, and T. Beal,Biol. Trace Ele. Res. 35, 239–246 (1992).Google Scholar
  17. 17.
    K. H. Schosinsky, H. P. Lehmann, and M. Beeler,Clin. Chem. 20, 1556–1563 (1974).PubMedGoogle Scholar
  18. 18.
    A. D. Hill, K. Y. Patterson, C. Veillon, and E. R. Morris,Anal. Chem. 58, 2340–2342 (1986).CrossRefGoogle Scholar
  19. 19.
    Perkin-Elmer Inc.Analytical Methods for Atomic Absorption Spectrophotometry, Norwalk, CT. (1976).Google Scholar
  20. 20.
    SAS Institute Inc.SAS User's Guide: Statistcis, 5th ed., Cary, NG., (1985).Google Scholar
  21. 21.
    J. Scholler, T. M. Farley, and K. Folkers,Internat. Z. Vit. Forschung 38, 362–368 (1968).Google Scholar
  22. 22.
    J. R. Prohaska and L. J. Heller,J. Nutr. 112, 2142–2150 (1982).PubMedGoogle Scholar
  23. 23.
    J. R. Goodman, J. B. Warshaw, and P. R. Dallman,Pediat. Res. 4, 244–256 (1970).PubMedCrossRefGoogle Scholar
  24. 24.
    P. R. Dallman and J. R. Goodman,Blood 35, 496–505 (1970).PubMedGoogle Scholar
  25. 25.
    S. J. Kopp, L. M. Klevay, and J. M. Feliksik,Am. J. Physiol. 245, H855-H866 (1983).PubMedGoogle Scholar
  26. 26.
    M. Gupta and P. K. Singal,Circ. Res. 64, 398–406 (1989).PubMedGoogle Scholar
  27. 27.
    W. Bohnenkamp and U. Weser,Biochim. Biophys. Acta 444, 396–406 (1976).PubMedGoogle Scholar
  28. 28.
    C. G. Taylor, W. J. Bettger, and T. M. Bray,J. Nutr. 118, 613–621 (1988).PubMedGoogle Scholar
  29. 29.
    C. Guarnieri, C. Muscari, and C. M. Caldarera,Advances in Myocardiology, P. Harris and P. A. Poole-Wilson, eds. vol. 5, Plenum Publishing Co., New York, 1985, pp. 191–199.Google Scholar
  30. 30.
    P. J. Quinn, H. Baun, E. J. Harris, C. S. Franklin, and P. Trivedi,Biomedical and Clinical Aspects of Coenzyme Q, vol. 2. Y. Yamamura, K. Folkers, and Y. Ito, eds. Elsevier Biomedical Press, Amsterdam, North-Holland, 1980, pp. 435–446.Google Scholar
  31. 31.
    W. G. Nayler,Biomedical and Clinical Aspects of Coenzyme Q, vol. 2, Y. Yamamura, K. Folkers, Y. Ito, eds. Elsevier Biomedical Press, Amsterdam, North-Holland, 1980, pp. 409–425.Google Scholar

Copyright information

© The Humana Press, Inc 1993

Authors and Affiliations

  • Charles G. Lewis
    • 1
  • Meira Fields
    • 2
  • Willard A. Burns
    • 3
  • Mark D. Lure
    • 1
  1. 1.ARS, BHNRC, Carbohydrate Nutrition LaboratoryUSDABeltsville
  2. 2.Division of EndocrinologyGeorgetown University Medical CenterWashington, D.C.
  3. 3.Laboratory ServiceVeterans Administration HospitalEast Orange

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