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Applied Biochemistry and Biotechnology

, Volume 10, Issue 1–3, pp 263–265 | Cite as

Preparation and in vivo studies of a new drug delivery system

Nanoparticles of alkylcyanoacrylate
  • P. Maincent
  • J. P. Devissaguet
  • R. LeVerge
  • P. A. Sado
  • P. Couveur
Drug Delivery Systems

Abstract

Polyhexylcyanoacrylate nanoparticles have been prepared with vincamine as the model drug. These particles had an average size of 200 nm and adsorbed approximately 435 of vincamine. The adsorption of vincamine to nanoparticles modified the distribution of vincamine in tissues. After iv injection the distribution volumes were increased in comparison with an aqueous solution of drug. In comparison with an aqueous solution of drug, the absolute bioavailability of vincamine was also increased after an oral administration of nanoparticles.

Index Entries

Polyhexyl cyanoacrylate, nanoparticles of vincamine, adsorbed onto nanoparticles pharmacokinetics and biopharmaceutics of nanoparticles nanoparticles, of alkylcyanoacrylate bioavailability, increases from nanoparticles 

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References

  1. 1.
    Couvreur, P., Kante, B., Lenaerts, V., Scailleur, V., Roland, M., and Speiser, P. (1980),J. Pharm. Sci. 63, 2, 199.CrossRefGoogle Scholar
  2. 2.
    Couvreur, P., Kante, B., and Roland, M. (1978),Pharm. Acta. Helv. 53, 12, 341.Google Scholar

Copyright information

© Humana Press Inc. 1984

Authors and Affiliations

  • P. Maincent
    • 1
  • J. P. Devissaguet
    • 1
  • R. LeVerge
    • 2
  • P. A. Sado
    • 2
  • P. Couveur
    • 3
  1. 1.Centre d’Etudes PharmaceutiquesChatenay MalabryParis XIFrance
  2. 2.Faculte de PharmacieRennesFrance
  3. 3.Faculte de PharmacieUCLBruxelsBelgium

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