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Preparation and in vivo studies of a new drug delivery system

Nanoparticles of alkylcyanoacrylate

  • Drug Delivery Systems
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Abstract

Polyhexylcyanoacrylate nanoparticles have been prepared with vincamine as the model drug. These particles had an average size of 200 nm and adsorbed approximately 435 of vincamine. The adsorption of vincamine to nanoparticles modified the distribution of vincamine in tissues. After iv injection the distribution volumes were increased in comparison with an aqueous solution of drug. In comparison with an aqueous solution of drug, the absolute bioavailability of vincamine was also increased after an oral administration of nanoparticles.

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References

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Author notes

  1. P. Maincent

    Present address: Laboratoire de Pharmacie Galénique, Faculte des Sciences Pharmaceutiques et Biologiques, Universite de Nancy, 5, rue Albert Lebrun, BP 403, 54001, Nancy Cedex, France

Authors and Affiliations

  1. Centre d’Etudes Pharmaceutiques, Chatenay Malabry, Paris XI, France

    P. Maincent & J. P. Devissaguet

  2. Faculte de Pharmacie, Rennes, France

    R. LeVerge & P. A. Sado

  3. Faculte de Pharmacie, UCL, Bruxels, Belgium

    P. Couveur

Authors
  1. P. Maincent
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  2. J. P. Devissaguet
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  3. R. LeVerge
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  4. P. A. Sado
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  5. P. Couveur
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Maincent, P., Devissaguet, J.P., LeVerge, R. et al. Preparation and in vivo studies of a new drug delivery system. Appl Biochem Biotechnol 10, 263–265 (1984). https://doi.org/10.1007/BF02783760

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  • DOI: https://doi.org/10.1007/BF02783760

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