Microcapsules for new animal drugs
- 42 Downloads
Microencapsulation techniques have been developed and refined for many years. However, in recent years, great strides have been made in controlling the microcapsule size down to the nanometer range when necessary. Progress has also been made in controlling the ratio of wall/capsule and the distribution of microcapsule diameter size in the batching of the capsules.
One area of application for microencapsulation is the convenience of dosing large groups of animals once with a sustained-release dosage form rather than with repeated administration since this involves greater effort at animal management.
For example, targeted dosages can be achieved by a specialized drug delivery system. Since animal systems are varied and ruminant animals have a digestive system that is different from and more complex than that of other animals, oral administration of a drug substance to be retained through the rumen to the abomasum for subsequent dissolution and/or excretion may be affected by a microencapsulation process. Miller and Gordon of USDA achieved this for control of fecal breeding flies by systemic retention of a microencapsulated pesticide drug into the manure.
Perhaps one of the most challenging areas is that of pharmaceuticals. There is now considerable interest in the area of microparticulate drug delivery systems. Examples of how desirable nutritional properties and taste preference are achieved and how these provide improved animal products will be discussed. Additional areas of interest and some possible future systems that have advantages over conventional systems will be discussed.
A brief description of some general requirements by the Food and Drug Administration (FDA) for approval of these drug delivery systems will be presented.
Index EntriesMicrocapsules, for animal drugs animal drugs, microcapsules for drugs, microcapsules for animal
Unable to display preview. Download preview PDF.
- 1.Bakan, J. A., and Anderson, J. L. (1970), “The Theory and Practice of Industrial Pharmacy,” inMicroencapsulation (L. Lachman, H. A. Liberman, and J. L. Ranig, eds.), pp. 384–407, Lea and Febiger, Philadelphia.Google Scholar
- 2.Bell, S. A., Berdick, M., and Holliday, W. M. (1966),J. New Drugs 6, No. 5.Google Scholar
- 3.Chang, T. M. S., MacIntosh, F. C., and Mason, S. G. (1966),Can. J. Physiol. Pharmacol. 44, 115.Google Scholar
- 7.Sparks, R. E., (1968), paper presented at Microencapsulation Workshop, Hopatcong, New Jersey, September 1968.Google Scholar
- 8.Chang, T. M. S. (1972),Artificial Cells, Charles C Thomas, Springfield, IL.Google Scholar
- 9.US Patent 3,577,515, J. E. Vandegaer to Pennwalt Corp.Google Scholar
- 10.Miller, R. W. and Gordon, C. H. (1972),Econ. Entomol. 65, 455.Google Scholar
- 11.Chem. Eng. News, July 31, 1971, p. 11.Google Scholar
- 13.Sparks, R. E. (1971), Microencapsulation Course, Sept. 26–28, 1971, Woodbridge, NJ.Google Scholar
- 14.Chem. Eng. News, August 12, 1974.Google Scholar
- 15.DeSavigny, C. B., and Ivy, E. E. (1974), “Microencapsulated Pesticides,” inMicroencapsulation: Processes and Applications”, Vandegaer, J. E., ed., Plenum, New York.Google Scholar
- 16.Quick Frozen Foods Magazine, November 1971.Google Scholar
- 17.Speiser, P. (1976), “Microencapsulation by Coacervation, Spray Encapsulation and Nanoencapsulation,” inMicroencapsulation, Nixon, J. R. ed. Dekker, New York.Google Scholar
- 18.Abrams, J., and Hinkes, T. M. (1974),Pest Control 42, 14.Google Scholar
- 19.Render Magazine, August, 1976.Google Scholar
- 20.Chem. Eng. News, June 28, 1976.Google Scholar
- 21.Santos, A. (1975), Summary of Results of Laboratory Screening of Compound 443A Against O. Quadrasi Contr. Rel. Mollusci, Newsletter, Univ. of Akron, April pp. 504.Google Scholar
- 22.Feedstuffs, March 7, 1977.Google Scholar
- 24.Bureau of Veterinary Medicine Stability Guidelines, February 1, 1978.Google Scholar
- 27.Chem. Eng. News, p. 43, Jan. 25, 1982.Google Scholar
- 28.Langer, R. (Feb. 1982),Chemtech. 98.Google Scholar
- 30.Sheumaker, J. L. (1983),Microparticulate Drug, Delivery Systems: Microcapsules, Nanoparticles and Liposomes, 18th Arden House Conference, Ind. Pharm. Sec. APhA, Harriman, NY.Google Scholar
- 31.Oppenheim, R. C. (ibid) (1983),Microparticulate Drug, Delivery Systems: Microcapsules, Nanoparticles and Liposomes, 18th Arden House Conference, Ind. Pharm. Sec. APhA, Harriman, NY.Google Scholar
- 32.Hunt, C. A. (ibid) (1983),Microparticulate Drug, Delivery Systems: Microcapsules, Nanoparticles and Liposomes, 18th Arden House Conference, Ind. Pharm. Sec. APhA, Harriman, NY.Google Scholar
- 33.DeLuca, P. P. (ibid) (1983),Microparticulate Drug, Delivery Systems: Microcapsules, Nanoparticles and Liposomes, 18th Arden House Conference, Ind. Pharm. Sec. APhA, Harriman, NY.Google Scholar