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A blood substitute from hydroxyethyl starch and hemoglobin

  • Artificial Red Blood Cell Substitutes
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Abstract

One method to increase the retention time of hemoglobin (Hgb) is to react it with a hydroxyethyl starch (HES) molecule. To examine this hypothesis, polymer-bound hemoglobin compounds were synthesized by the dialdehyde route. The electrophoretic mobility patterns indicate complete binding of the Hgb. Preliminary exchange-transfusion experiments in rates showed that they could survive for at least 10 h at Hct<10% when transfused with 6% HES-Hgb solutions. The retention time of the Hgb in the urine was increased to 12 h with these new polymers.

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References

  1. Cerny, L. C., Stasiw, D. M., Cerny, E. L., Baldwin, J. E., and Gill, B. (1982),Clin. Hemorheology 2, 355.

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Authors and Affiliations

  1. The Masonic Medical Research Laboratory and Utica College of Syracuse University, Utica, NY

    L. C. Cerny, E. L. Cerny, J. Robach, M. Reath & L. Pontero

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  1. L. C. Cerny
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  2. E. L. Cerny
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  3. J. Robach
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  4. M. Reath
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  5. L. Pontero
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Cerny, L.C., Cerny, E.L., Robach, J. et al. A blood substitute from hydroxyethyl starch and hemoglobin. Appl Biochem Biotechnol 10, 151–153 (1984). https://doi.org/10.1007/BF02783747

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  • DOI: https://doi.org/10.1007/BF02783747

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