Biological Trace Element Research

, Volume 60, Issue 1–2, pp 139–144 | Cite as

Depressed antioxidant defense in rat heart in experimental magnesium deficiency implications for the pathogenesis of myocardial lesions

  • B. Prakash Kumar
  • K. Shivakumar
Original Articles


Magnesium (Mg) deficiency has been shown to produce myocardial lesions in different experimental models. Based on several lines of evidence, it has been proposed that oxidative injury to the cardiac muscle may explain the pathobiology of such lesions. In pursuance of this postulation, the present study examined the effect of dietary deficiency of Mg on the activity of the antioxidant enzymes, Superoxide dismutase (SOD) and catalase, in rat heart. This article reports a significant lowering of the activity of both these enzymes in the cardiac tissue in Mg-deficient rats. Since depressed antioxidant defense in the heart may enhance myocardial susceptibility to oxidative injury, the observation is of possible relevance to the pathogenesis of cardiac lesions in Mg deficiency.

Index Entries

Magnesium deficiency heart cardiomyopathy superoxide dismutase catalase 


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Copyright information

© Humana Press Inc. 1997

Authors and Affiliations

  • B. Prakash Kumar
    • 1
  • K. Shivakumar
    • 1
  1. 1.Division of Cellular and Molecular CardiologySree Chitra Tirunal Institute for Medical Sciences & TechnologyTrivandrumIndia

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