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Biological Trace Element Research

, Volume 59, Issue 1–3, pp 159–165 | Cite as

Effect of lithium on hepatic drug-metabolizing enzymes of protein-deficient rats

  • Aparna Tandon
  • J. P. Nagpaul
  • D. K. Dhawan
Original Articles

Abstract

Protein deficiency was produced by feeding synthetic 8%-protein diet. Lithium carbonate at the dose level of 1.1g/kg diet was administered to normal and protein-deficient rats for a period of one mo. A significant inhibition in the levels of cytochrome (cyt) P450, cyt b5, glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx), but an increase in γ-glutamyl transpeptidase (γ-GT), was observed in low-protein LP-fed rats. Lithium treatment to normal rats caused no significant change in the activities of cyt P450, cyt b5, GST, and GSH levels, whereas there was elevation in the activities of γ-GT and GPx and suppression in glutathione reductase (GRd) activity. Lithium administration to LP-fed rats resulted in significant increases in the hepatic γ-GT and GPx activities.

Index Entries

Lithium low protein diet drug-metabolizing enzymes 

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References

  1. 1.
    P. C. Baastrup and M. Schou,Arch. Gen. Psychiatr. 16, 162–172 (1967).PubMedGoogle Scholar
  2. 2.
    R. J. Baldessarini and J. H. Stephens,Arch. Gen. Psychiatr. 22, 72–77 (1970).PubMedGoogle Scholar
  3. 3.
    N. Kline,Am. J. Psychiatr. 125, 558–560 (1968).PubMedGoogle Scholar
  4. 4.
    D. Dhawan, A. Kumari, A. Karihaloo, and N. K. Relan,J. Neurochem. (S),48, 76 (1987).Google Scholar
  5. 5.
    S. S. Parmar, B. Ali, H. W. Spencer, and T. K. Auyong,Res. Commun. Chem. Pathol. Pharmacol. 7, 633–636 (1974).PubMedGoogle Scholar
  6. 6.
    G. E. Hunt, G. R. Beilharz, L. H. Storlein, P.W. Kuchel, and G. F. S. Johnson,Biochem. Pharmacol. 32, 2981–2983 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    Y. Aniya and K. Matsusaki,Japan. J. Pharmacol. 33, 647–653 (1983).Google Scholar
  8. 8.
    N. Kato, T. Tani, and A. Yoshida,J. Nutr. 110, 1686–1694 (1980).PubMedGoogle Scholar
  9. 9.
    N. Ammigan, U. J. Nair, and S. V. Bhide,Nutr. Res. 9, 1397–1405 (1989).CrossRefGoogle Scholar
  10. 10.
    J. R. Claude, J. M. Warnet, M. Boucard, J. J. Serrano, M. Thevenin, I. Bakar-Wesseling, and A. Jacqueson,Ann. Pharm. Fr. 45, 195–204 (1987).PubMedGoogle Scholar
  11. 11.
    A. Ayala, E. Gordillo, A. Castano, M. F. Labato, and A. Machado,Biochim. Biophys. Acta. 1084, 48–52 (1991).PubMedGoogle Scholar
  12. 12.
    S. Hum, K. C. Roski, and L. J. Hoffer,J. Nutr.122, 2010–2018 (1992).PubMedGoogle Scholar
  13. 13.
    M. A. Pelissier, M. Boisset, S. Atteba, and R. Albercht,Food Addit. Contam. 7, S172-S177 (1990).PubMedGoogle Scholar
  14. 14.
    C. J. Huang and M. L. Fwu,J. Nutr. 123, 803–810 (1993).PubMedGoogle Scholar
  15. 15.
    J. R. Hayes, M. U. K. Mgbodile, and T. C. Campbell,Biochem. Pharmacol. 22, 1005–1014 (1973).PubMedCrossRefGoogle Scholar
  16. 16.
    J. Kaur, V. M. S. Jaswal, J. P. Nagpaul, and A. Mahmood,Nutrition 8, 338–342 (1992).PubMedGoogle Scholar
  17. 17.
    D. Dhawan, R. R. Sharma, and R. J. Dash,Horm. Metabol. Res. 17, 109–110 (1985).Google Scholar
  18. 18.
    P. B. Brown and E. F. Legg,Annal. Clin. Biochem. 7, 13–17 (1970).Google Scholar
  19. 19.
    T. Omura and R. Sato,J. Biol. Chem. 239, 2370–2378 (1964).PubMedGoogle Scholar
  20. 20.
    M. S. Moron, W. D. Joseph, and B. Mannervik,Biochim. Biophys. Acta. 582, 67–78 (1979).PubMedGoogle Scholar
  21. 21.
    W. H. Habig, M. J. Palist, and W. B. Jakoby,J. Biol. Chem. 249, 7130–7139 (1974).PubMedGoogle Scholar
  22. 22.
    C. H. Williams, Jr. and I. D. Arscott, Glutathione reductase,Methods Enzymol. 17, 503–509 (1971).CrossRefGoogle Scholar
  23. 23.
    L. Naftalin, J. F. Whitaker, and D. Tracey,Clin. Chim. Acta. 26, 293–296 (1969).PubMedCrossRefGoogle Scholar
  24. 24.
    L. Flohe and W. A. Gunzler, Assay of glutathione peroxidase,Methods Enzymol. 105, 114–126 (1984).PubMedGoogle Scholar
  25. 25.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall,J. Biol. Chem. 193, 265–275 (1951).PubMedGoogle Scholar
  26. 26.
    G. R. Reddy, T. More, and L. N. Singh,Med. Sci. Res. 15, 493–494 (1987).Google Scholar
  27. 27.
    W. G. Pond, K. J. Ellis, and P. Schoknecht,Proc. Soc. Exp. Med. 200, 556–561 (1992).Google Scholar
  28. 28.
    Y. Israel, H. Speisky, A. J. Lanca, S. Iwamura, M. Hirai, and G. Varghese, Metabolism of hepatic glutathione and its relevance to alcohol induced liver damage,Cellular Mol. Aspects Cirrhosis 216, 25–37 (1992).Google Scholar

Copyright information

© Humana Press Inc. 1997

Authors and Affiliations

  • Aparna Tandon
    • 1
  • J. P. Nagpaul
    • 1
  • D. K. Dhawan
    • 2
  1. 1.Department of BiochemistryPanjab UniversityChandigarhIndia
  2. 2.Department of BiophysicsPanjab UniversityChandigarhIndia

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