Biological Trace Element Research

, Volume 59, Issue 1–3, pp 159–165 | Cite as

Effect of lithium on hepatic drug-metabolizing enzymes of protein-deficient rats

  • Aparna Tandon
  • J. P. Nagpaul
  • D. K. Dhawan
Original Articles


Protein deficiency was produced by feeding synthetic 8%-protein diet. Lithium carbonate at the dose level of 1.1g/kg diet was administered to normal and protein-deficient rats for a period of one mo. A significant inhibition in the levels of cytochrome (cyt) P450, cyt b5, glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx), but an increase in γ-glutamyl transpeptidase (γ-GT), was observed in low-protein LP-fed rats. Lithium treatment to normal rats caused no significant change in the activities of cyt P450, cyt b5, GST, and GSH levels, whereas there was elevation in the activities of γ-GT and GPx and suppression in glutathione reductase (GRd) activity. Lithium administration to LP-fed rats resulted in significant increases in the hepatic γ-GT and GPx activities.

Index Entries

Lithium low protein diet drug-metabolizing enzymes 


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Copyright information

© Humana Press Inc. 1997

Authors and Affiliations

  • Aparna Tandon
    • 1
  • J. P. Nagpaul
    • 1
  • D. K. Dhawan
    • 2
  1. 1.Department of BiochemistryPanjab UniversityChandigarhIndia
  2. 2.Department of BiophysicsPanjab UniversityChandigarhIndia

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