Abstract
An in vivo luminal perfusion technique was used to investigate the influence of Ca, Mg, lactose, and glucose on Mn absorption in different segments of the rat intestine. Mn absorption was determined by measuring disappearance of54Mn activity from the perfusion solution containing 0.1 or 0.01 mmol/L Mn. Na and water absorption were also determined.
Mn absorption decreased during the first 30 min of perfusion to reach a steady state thereafter. Ca (1 mmol/L) inhibited Mn absorption in the proximal jejunum and in the colon, whereas Mn absorption was increased by Ca in the distal jejunum. Mg (1 mmol/L), lactose, and glucose (25 mmol/L each) had no effect on Mn absorption in the jejunum. These results can be explained by a direct interaction of Mn and Ca during transcellular Ca transport in the proximal jejunum and colon. The reason for the stimulatory effect of Ca in the distal jejunum is unknown.
Similar content being viewed by others
References
A. R. Kemmerer, C. A. Elvehjem, and E. B. Hart,J. Biol. Chem. 92, 623–630 (1931).
E. R. Orent and E. V. McCollum,J. Biol. Chem. 92, 651–678 (1931).
R. A. Wapnir, ed.,Protein Nutrition and Mineral Absorption, CRC Press (1990), pp. 243–257.
D. Y. Lee and P. E. Johnson,J. Nutr. 118, 1509–1516 (1988).
J. M. Johnson and C. Kies,Nutr. Rep. Internat. 39, 687–696 (1989).
A. B. R. Thomson, D. Olatunbosun, and L. S. Valberg,J. Lab. Clin. Med. 78, 642–655 (1971).
A. B. R. Thomson, L. S. Valberg, and D. G. Sinclair,J. Clin. Invest. 50, 2384–2394 (1971).
A. B. R. Thomson and L. S. Valberg,Am. J. Physiol. 223, 1327–1329 (1972).
J. A. Garcia-Aranda, R. A. Wapnir, and F. Lifshitz,J. Nutr. 113, 2601–2607 (1983).
L. Rossander-Hulten, M. Brune, B. Sandström, B. Lönnerdal, and L. Halberg,Am. J. Clin. Nutr. 54, 152–156 (1991).
A. A. VanBarneveld, and C. J. A. Van den Hamer,Biol. Trace Element Res. 6, 489–505 (1984).
P. E. Johnson and G. I. Lykken,J. Trace Element Exp. Med. 4, 19–35 (1991).
L. Davidsson, A. Cederblad, B. Lönnerdal, and B. Sandström,Am. J. Clin. Nutr. 54, 1065–1070 (1991).
P. Fournier and A. Fournier,Comptes R. Soc. Biol. 166, 29–31 (1972).
B. D. King, J. W. Lassiter, M. W. Neathery, W. J. Miller, and R. P. Gentry,J. Anim. Sci. 50, 452–458 (1980).
M. M. Petith and H. P. Schedl,Am. J. Dig. Dis. 23, 1–5 (1978).
F. Bronner,Miner. Electrol. Metab. 16, 94–100 (1990).
A. Miller III, F. Bronner, and S. T. Li,Biochem. J. 208, 773–781 (1982).
R. J. Ingersoll and R. H. Wassrman,J. Biol. Chem. 246, 2808–2814 (1971).
U. Karbach, A. Schmitt, and F. H. Saner,Dig. Dis. Sci. 36, 1611–1618 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lutz, T.A., Schroff, A. & Scharrer, E. Effects of calcium and sugars on intestinal manganese absorption. Biol Trace Elem Res 39, 221–227 (1993). https://doi.org/10.1007/BF02783192
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02783192