Network of cytokine and arachidonic acid cascade in acute hepatic failure
- 10 Downloads
When heat-killedPropionibacterium acnes (P. acnes) was intravenously injected into mice and 7 days later a small amount of lipopolysaccharide (LPS) endotoxin was administered, most of the mice died of massive liver necrosis. In this liver injury model, cytokines, immunomediators, and eicosanoids, inflammatory products, were produced by Kupffer cells and liver-infiltrated macrophages, which were thought to participate, directly or indirectly, in the induction of liver cell damage. Furthermore, these two networks seemed to regulate each other. Thus, this regulatory mechanism might play an important role in the induction of liver cell injury.
KeywordsAcne Kupffer Cell Azelastin Acute Hepatic Failure Arachidonic Acid Cascade
Unable to display preview. Download preview PDF.
- 1.Tsutsui H, Mizoguchi Y, Yamamoto S, et al. Studies on experimentally-induced acute hepatic failure: possible involvement of activated liver adherent cells. In: Kirn A, Knook KS, Wisse E, eds. Cells of the hepatic sinusoid, Vol. I. The Netherlands: The Kupffer Cell Foundation, 1986;307–314.Google Scholar
- 8.Brets U, Dewald B, Payne T, et al. Phagocytosis stimulates the release of a slow reacting substance in cultured macrophages. Br J Pharmacol 1980;71:631–634.Google Scholar
- 12.Kawada N, Kuboi H, Shin T, et al. Effect of tumor necrosis factor α and interleukin la on prostaglandin E2 synthesis by mouse Kupffer cells. Acta Hepat Jap 1989;30:855–859. (in Japanese)Google Scholar
- 13.Kawada N, Mizoguchi Y, Ichikawa Y, et al. Production of tumor necrosis factor by liver adherent cells and its regulation with prostaglandins. Acta Hepat Jap 1990;31:130–138. (in Japanese)Google Scholar