Gastroenterologia Japonica

, Volume 28, Supplement 4, pp 30–32 | Cite as

Network of cytokine and arachidonic acid cascade in acute hepatic failure

  • Yasuhiro Mizoguchi
  • Norifumi Kawada
  • Hiroko Tsutsui
  • Kenzo Kobayashi
Hepatic Necrosis


When heat-killedPropionibacterium acnes (P. acnes) was intravenously injected into mice and 7 days later a small amount of lipopolysaccharide (LPS) endotoxin was administered, most of the mice died of massive liver necrosis. In this liver injury model, cytokines, immunomediators, and eicosanoids, inflammatory products, were produced by Kupffer cells and liver-infiltrated macrophages, which were thought to participate, directly or indirectly, in the induction of liver cell damage. Furthermore, these two networks seemed to regulate each other. Thus, this regulatory mechanism might play an important role in the induction of liver cell injury.


Acne Kupffer Cell Azelastin Acute Hepatic Failure Arachidonic Acid Cascade 


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Copyright information

© The Japanese Society of Gastroenterology 1993

Authors and Affiliations

  • Yasuhiro Mizoguchi
    • 1
  • Norifumi Kawada
    • 1
  • Hiroko Tsutsui
    • 2
  • Kenzo Kobayashi
    • 1
  1. 1.Third Department of Internal MedicineOsaka City University Medical SchoolOsakaJapan
  2. 2.The First Department of BiochemistryOsaka City University Medical SchoolOsakaJapan

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