Advertisement

Gastroenterologia Japonica

, Volume 26, Issue 4, pp 497–502 | Cite as

Clinicopathological studies on solid and cystic tumors of the pancreas

  • Nobuhiko Ueda
  • Takukazu Nagakawa
  • Tetsuo Ohta
  • Takashi Nakamura
  • Keiichi Ueno
  • Itsuo Miyazaki
  • Madoka Kurachi
  • Ichiroh Konishi
  • Teisuke Hirono
  • Nobutatu Takayanagi
  • Hiroshi Sodani
  • Shoichi Kanno
Liver, Pancreas and Biliary Tract
  • 13 Downloads

Summary

Three cases of pancreatic tumor in two females (case 1, case 3) and one male (case 2) were reported. Macroscopically cases 1 and 3, which were surrounded by a thick fibrous capsule, developed toward the outside of the pancreas and the cut surface showed mainly cystic degenerative areas filled with necrotic and hemorrhagic materials. In contrast with these two cases, case 2 was buried in the pancreatic tissue and the cut surface showed cystic degenerative areas in its center with a thick fibrous capsule and tumor cell nests invading beyond the capsule to the parenchyma of the pancreas. Microscopically each tumor was identical. The solid areas on the periphery were composed of sheets of polygonal uniform cells subdivided by delicate fibrovascular stalks. Near the degenerative areas, tumor cells lay on a delicate fibrovascular core in one or two layers, with pseudopapillary patterns. Mitotic figures were very rare. All three cases demonstrated immunoreactivity for alpha-1-antitrypsis, but not for islet hormones, tumor markers nor neuron-specific enolase. Although electronmicroscopically, zymogen granules were detected in cases 2 and 3, and annulate lamellae in cases 1 and 3, ductal cell character features were not so developed. From the above, these tumors were diagnosed as solid and cystic tumors of the pancreas. Furthermore, it was suggested that they differentiated in the direction of acinar cells.

Key words

alpha-1-antitrypsin pancreatic tumor solid and cystic tumor zymogen granule 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Klöppel G, Morohoshi T, John HD, et al: Solid and cystic acinar cell tumor of the pancreas. Virchows Arch 1981;392:171–183.CrossRefGoogle Scholar
  2. 2.
    Learmonth GM, Prince SK, Visser AE, et al: Papillary and cystic neoplasm of the pancreas-an acinar cell tumour? Histopathology 1985;9:63–79.PubMedCrossRefGoogle Scholar
  3. 3.
    Morrison DM, Jewell LD, McCaughey WTE, et al: Papillary cystic tumor of the pancreas. Arch Pathol Lab Med 1984;108: 723–727.PubMedGoogle Scholar
  4. 4.
    Yamaguchi T, Kobayashi Y, Ookawa J, et al: A case report of solid and cystic tumor of the pancreas in association with positve immunohistochemical staining of carbohydrate antigen 19-9. J Gastroenterol Surg 1989;22:965–968.Google Scholar
  5. 5.
    Kamisawa T, Fukayama M, Koike M, et al: So-called “papillary and cystic neoplasm of the pancreas”. Acta Pathol Jpn 1987;37: 785–794.PubMedGoogle Scholar
  6. 6.
    Matsuno H, Konishi F, Yamamichi N, et al: Papillary-cystic neoplasm of the pancreas-A proposal of calcifying-inverted variant. Biliary tract and Pancreas 1988;9:207–217.Google Scholar
  7. 7.
    Ray MB, Desmer VJ: Immunohistochemical demonstration of alpha-1-antitrypsin in the islet cells of human pancreas. Cell Tissue Res 1978;187:69–77.PubMedCrossRefGoogle Scholar
  8. 8.
    Ichihara T, Nakao A, Sakamoto J, et al: CA-50, CA19-9, DUPAN2 in pancreatic cancer patients (II). J Jpn Pnc Soc 1987;2:34–45.Google Scholar
  9. 9.
    Tapia FJ, Polak JM, Barbosa AJA, et al: Neuron-specific enolase is produced by neuroendocrine tumors. Lancet 1981;1: 808–811.PubMedCrossRefGoogle Scholar
  10. 10.
    Bishop AE, Polak JM, Facer P, et al: Neuron specific enolase. Gastroenterology 1982;83:902–915.PubMedGoogle Scholar
  11. 11.
    Lloyd RV, Warner TFCS, Mervak T, et al: Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms. Am J Surg Pathol 1984;8:607–614.PubMedCrossRefGoogle Scholar
  12. 12.
    Reid JD, Yuh SL, Petrelli M, et al: Ductuloinsular tumors of the pancreas. Cancer 1982;49:908–915.PubMedCrossRefGoogle Scholar
  13. 13.
    Polak JM, Bloom SR, Marangos PJ: Neuron-specific enolase. In: Falkmer S, Hakanson R, Sundler F, eds. Evolution and tumour pathology of the neuroendocrine system. Elsevier Sci Publ, Amsterdam. 1984;433–452.Google Scholar
  14. 14.
    Yagihashi S, Sato I, Kaimori M, et al: Papillary and cystic tumor of the pancreas. Cancer 1988;61:1241–1247.PubMedCrossRefGoogle Scholar
  15. 15.
    Horie A, Morohoshi T, Klöppel G: Ultrastructural comparison of pancreatoblastoma, solid cystic tumor and acinar cell carcinoma. J Clin Electron Microscopy 1987;20:353–362.Google Scholar
  16. 16.
    Schlosnagle DC, Campbell WG: The papillary and solid neoplasm of the pancreas. Cancer 1981;47:2603–2610.PubMedCrossRefGoogle Scholar
  17. 17.
    Tanino M, Koide O, Hisatomi K, et al: A case of papillary-cystic neoplasm of the pancreas. Pathol and Clin 1985;3:1365–1370.Google Scholar
  18. 18.
    Hamoudi AB, Misugi K, Grosfeld JL: Papillary epithelial neoplasm of pancreas in a child. Cancer 1970;26:1126–1134.PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Society of Gastroenterology 1991

Authors and Affiliations

  • Nobuhiko Ueda
    • 1
  • Takukazu Nagakawa
    • 1
  • Tetsuo Ohta
    • 1
  • Takashi Nakamura
    • 1
  • Keiichi Ueno
    • 1
  • Itsuo Miyazaki
    • 1
  • Madoka Kurachi
    • 2
  • Ichiroh Konishi
    • 3
  • Teisuke Hirono
    • 3
  • Nobutatu Takayanagi
    • 4
  • Hiroshi Sodani
    • 5
  • Shoichi Kanno
    • 5
  1. 1.Second Department of Surgery, School of MedicineKanazawa UniversityKanazawaJapan
  2. 2.Department of SurgeryHouju HospitalKanazawaJapan
  3. 3.Departments of SurgeryToyama City HospitalToyamaJapan
  4. 4.Departments of PathologyToyama City HospitalToyamaJapan
  5. 5.Department of SurgeryKeiju HospitalNanaoJapan

Personalised recommendations